Slc7a8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
MGI:1355323

15 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc7a8^tm1Dgen/Slc7a8^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	decreased locomotor activity	J:101679
	decreased susceptibility to pharmacologically induced seizures	J:101679
	impaired coordination	J:101679
Slc7a8^tm1Geno/Slc7a8⁺ involves: 129 * C57BL/6J	abnormal spiral ligament fibrocyte morphology	J:256844
Slc7a8^tm1Geno/Slc7a8⁺ involves: 129 * C57BL/6J	impaired hearing	J:256844
Slc7a8^tm1Geno/Slc7a8^tm1Geno B6.Cg-Slc7a8^tm1Geno	impaired hearing	J:256844
Slc7a8^tm1Geno/Slc7a8^tm1Geno involves: 129 * C57BL/6J	abnormal auditory brainstem response waveform shape	J:256844
	abnormal spiral ligament fibrocyte morphology	J:256844
	abnormal spiral ligament morphology	J:256844
	abnormal strial basal cell morphology	J:256844
	cochlear ganglion degeneration	J:256844
	cochlear hair cell degeneration	J:256844
	decreased prepulse inhibition	J:256844
	normal homeostasis/metabolism phenotype	J:256844
	impaired coordination	J:256844
	impaired hearing	J:256844
	increased or absent threshold for auditory brainstem response	J:256844
Slc7a8^{tm2b(EUCOMM)Hmgu}/Slc7a8⁺ C57BL/6N-Slc7a8^{tm2b(EUCOMM)Hmgu}/Bay	decreased circulating fructosamine level	J:211773
	short tibia	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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