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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Phgdh
3-phosphoglycerate dehydrogenase
MGI:1355330
50 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Phgdhtm1.1Shfu/Phgdhtm1.1Shfu
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal brain development J:128777
abnormal embryonic neuroepithelial layer differentiation J:128777
abnormal embryonic/fetal subventricular zone morphology J:128777
abnormal nervous system development J:128777
abnormal neuron differentiation J:128777
absent cerebellum J:128777
absent olfactory bulb J:128777
decreased brain size J:128777
decreased embryo size J:128777
embryonic lethality during organogenesis, complete penetrance J:128777
enlarged lateral ventricles J:128777
exencephaly J:128777
forebrain hypoplasia J:128777
interdigital webbing J:128777
Phgdhtm1.2Shfu/Phgdhtm1.2Shfu
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * FVB/N 		decreased arginine level J:167572
decreased brain weight J:167572
decreased cystathionine level J:167572
decreased glutamic acid level J:167572
decreased glycine level J:167572
decreased phenylalanine level J:167572
decreased serine level J:167572
decreased threonine level J:167572
forebrain hypoplasia J:167572
increased arginine level J:167572
increased circulating glycine level J:167572
increased glutamine level J:167572
increased phenylalanine level J:167572
microcephaly J:167572
Phgdhtm1b(KOMP)Wtsi/Phgdh+
C57BL/6N-Phgdhtm1b(KOMP)Wtsi/Kmpc 		abnormal cornea morphology J:211773
cornea opacity J:211773
decreased fluid intake J:211773
decreased food intake J:211773
decreased respiratory quotient J:211773
no spontaneous movement J:211773
unresponsive to tactile stimuli J:211773
Phgdhtm1b(KOMP)Wtsi/Phgdhtm1b(KOMP)Wtsi
C57BL/6N-Phgdhtm1b(KOMP)Wtsi/Kmpc 		abnormal blood vessel morphology J:211773
abnormal embryo development J:211773
abnormal embryo size J:211773
abnormal embryo turning J:211773
abnormal eye morphology J:211773
abnormal head shape J:211773
abnormal head size J:211773
abnormal hindbrain morphology J:211773
abnormal visceral yolk sac morphology J:211773
abnormal vitelline vasculature morphology J:211773
edema J:211773
embryonic growth retardation J:211773
hemorrhage J:211773
microphthalmia J:211773
prenatal lethality J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory