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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Olig2
oligodendrocyte transcription factor 2
MGI:1355331
70 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 		increased oligodendrocyte number J:285841
Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal brain development J:285841
abnormal brainstem morphology J:285841
abnormal glial cell physiology J:285841
ataxia J:285841
muscle spasm J:285841
normal neoplasm J:285841
preweaning lethality, incomplete penetrance J:285841
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N 		increased brain tumor incidence J:285841
increased glioma incidence J:285841
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N 		increased brain tumor incidence J:285841
increased glioma incidence J:285841
Acvr1tm1Mak/Acvr1+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		normal neoplasm J:285841
postnatal lethality, incomplete penetrance J:285841
Cdh2tm1Glr/Cdh2tm1Glr
Olig2tm1(cre)Tmj/Olig2+
involves: 129S6/SvEvTac 		abnormal neuronal migration J:178688
abnormal spinal cord morphology J:178688
abnormal spinal cord motor column morphology J:178688
lethality throughout fetal growth and development, incomplete penetrance J:178688
neonatal lethality, complete penetrance J:178688
Cspg4tm1Ychan/Cspg4tm1Ychan
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6N 		decreased body weight J:184220
decreased epididymal fat pad weight J:184220
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Juptm1Ruiz/Juptm1.1Tmj
Olig2tm1(cre)Tmj/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal dendrite morphology J:178688
lethality throughout fetal growth and development, complete penetrance J:178688
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Juptm1Ruiz/Juptm1Ruiz
Olig2tm1(cre)Tmj/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal neuronal migration J:178688
abnormal spinal cord lateral motor column morphology J:178688
abnormal spinal cord medial motor column morphology J:178688
abnormal spinal cord motor column morphology J:178688
abnormal ventral interneuron 1 morphology J:178688
abnormal ventral interneuron 2 morphology J:178688
decreased motor neuron number J:178688
embryonic lethality during organogenesis, complete penetrance J:178688
normal nervous system phenotype J:178688
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Olig2tm1(cre)Tmj/Olig2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord medial motor column morphology J:178688
decreased motor neuron number J:178688
neonatal lethality, complete penetrance J:178688
Gt(ROSA)26Sorem2(Mios)Bcgen/Gt(ROSA)26Sor+
Miostm1Pfw/Miostm1Pfw
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6 		normal nervous system phenotype J:320720
Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129P2/OlaHsd 		abnormal brain development J:193058
decreased oligodendrocyte progenitor number J:193058
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N 		normal neoplasm J:285841
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N 		normal neoplasm J:285841
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * 129X1/SvJ 		increased medulloblastoma incidence J:139574
premature death J:139574
Mapttm1(Sema3e)Yuyo/Mapt+
Olig2tm1(cre)Tmj/Olig2+
Not Specified 		abnormal excitatory postsynaptic potential J:205528
abnormal sensory neuron innervation pattern J:205528
abnormal synaptic bouton morphology J:205528
normal nervous system phenotype J:205528
Miostm1Pfw/Miostm1Pfw
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6 		abnormal oligodendrocyte physiology J:320720
normal behavior/neurological phenotype J:320720
decreased oligodendrocyte number J:320720
dysmyelination J:320720
Myrftm1Barr/Myrftm1Barr
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal myelination J:150563
abnormal optic nerve morphology J:150563
abnormal spinal cord morphology J:150563
ataxia J:150563
normal nervous system phenotype J:150563
postnatal lethality, complete penetrance J:150563
seizures J:150563
tremors J:150563
Ntf3tm2.1Jae/Ntf3tm2Jae
Olig2tm2(cre)Htak/Olig2+
Not Specified 		abnormal dorsal root ganglion morphology J:182750
abnormal proprioceptive neuron morphology J:182750
abnormal sensory neuron innervation pattern J:182750
Olig1tm1And/Olig1tm1And
Olig2tm1And/Olig2tm1And
involves: 129 * C57BL/6J 		abnormal nervous system development J:76446
abnormal ventral interneuron 2 morphology J:76446
absent oligodendrocytes J:76446
decreased fetal size J:76446
decreased motor neuron number J:76446
decreased oligodendrocyte progenitor number J:76446
perinatal lethality, complete penetrance J:76446
Olig1tm1And/Olig1tm1And
Olig2tm1And/Olig2tm1And
Tg(Olig2)#Wdr/?
Not Specified 		abnormal oligodendrocyte morphology J:210099
Olig2tm1(cre)Tmj/Olig2+
Shhtm2Amc/Shhtm2Amc
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord lateral motor column morphology J:277700
decreased motor neuron number J:277700
normal nervous system phenotype J:277700
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:164292
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129 * 129P2/OlaHsd * FVB/N 		abnormal CNS synaptic transmission J:164292
abnormal miniature endplate potential J:164292
abnormal muscle morphology J:164292
abnormal neuromuscular synapse morphology J:164292
abnormal PNS synaptic transmission J:164292
abnormal sensory neuron innervation pattern J:164292
abnormal synaptic bouton morphology J:164292
abnormal synaptic transmission J:164292
decreased body weight J:164292
decreased grip strength J:164292
decreased skeletal muscle fiber number J:164292
decreased survivor rate J:164292
increased skeletal muscle fiber size J:164292
kyphosis J:164292
motor neuron degeneration J:164292
muscle weakness J:164292
muscular atrophy J:164292
premature death J:164292
skeletal muscle fiber degeneration J:164292
Prrc2atm1Fcw/Prrc2atm1Fcw
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6 		abnormal brain morphology J:301796
abnormal corpus callosum morphology J:301796
decreased body weight J:301796
decreased grip strength J:301796
decreased oligodendrocyte number J:301796
decreased oligodendrocyte progenitor number J:301796
dysmyelination J:301796
enlarged lateral ventricles J:301796
impaired coordination J:301796
impaired spatial learning J:301796
increased brain weight J:301796
normal nervous system phenotype J:301796
premature death J:301796
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory