Atoh7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atoh7
atonal bHLH transcription factor 7
MGI:1355553

39 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atoh7^{tm1(Neurod1)Whk}/Atoh7^{tm2(Neurod4)Whk} involves: 129S6/SvEvTac * C57BL/6	abnormal optic nerve morphology	J:141248
	increased retina apoptosis	J:141248
	increased retina photoreceptor cell number	J:141248
	optic nerve hypoplasia	J:141248
	normal vision/eye phenotype	J:141248
Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7^{tm1.1(Ascl1)Nlbr} either: 129(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or B6.129S6(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)	abnormal Muller cell morphology	J:203642
	abnormal retina bipolar cell morphology	J:203642
	abnormal retina vasculature morphology	J:203642
	absent optic nerve	J:203642
	decreased retina ganglion cell number	J:203642
	decreased total retina thickness	J:203642
	increased retina cone cell number	J:203642
Atoh7^tm1.1Xmu/Atoh7^tm1.1Xmu involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:151244
Atoh7^tm1Gan/Atoh7^{tm1(Neurod1)Whk} involves: 129S6/SvEvTac * C57BL/6	abnormal optic nerve morphology	J:141248
	decreased retina ganglion cell number	J:141248
	increased retina apoptosis	J:141248
	optic nerve hypoplasia	J:141248
Atoh7^tm1Gan/Atoh7^tm1Gan B6.Cg-Atoh7^tm1Gan	abnormal eye electrophysiology	J:135827
	abnormal Muller cell morphology	J:135827
	abnormal retina ganglion cell morphology	J:135827
	abnormal retina morphology	J:135827
	decreased retina ganglion cell number	J:135827
	increased retina apoptosis	J:135827
	optic nerve hypoplasia	J:135827
Atoh7^tm1Gan/Atoh7^tm1Gan involves: 129S/SvEv * C57BL/6J	increased amacrine cell number	J:67382
Atoh7^tm1Gan/Atoh7^tm1Gan involves: 129S/SvEv * C57BL/6J	normal reproductive system phenotype	J:67382
Atoh7^tm1Gan/Atoh7^tm1Gan Not Specified	abnormal retina cone bipolar cell morphology	J:119663
	absent optic nerve	J:141248
	absent retina ganglion cell	J:141248
	increased amacrine cell number	J:119663
Atoh7^tm1Gan/Atoh7^{tm2(Neurod4)Whk} involves: 129S6/SvEvTac * C57BL/6	absent optic nerve	J:141248
	decreased retina ganglion cell number	J:141248
Atoh7^tm1Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal retina ganglion cell morphology	J:67382
Atoh7^tm1Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal retina nerve fiber layer morphology	J:67382
Atoh7^tm1Gla/Atoh7^tm1Gla B6.129-Atoh7^tm1Gla	abnormal circardian behavior entrainment	J:99410
	abnormal eye electrophysiology	J:99410
	abnormal retina bipolar cell morphology	J:99410
	abnormal retina cone bipolar cell morphology	J:99410
	abnormal retina rod bipolar cell morphology	J:99410
	absent optic tract	J:99410
	decreased retina rod cell number	J:99410
	thin retina inner nuclear layer	J:99410
	thin retina inner plexiform layer	J:99410
	thin retina outer nuclear layer	J:99410
	thin retina outer plexiform layer	J:99410
Atoh7^tm1Gla/Atoh7^tm1Gla either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal cell cycle	J:110600
	abnormal eye development	J:110600
	abnormal retina cone cell morphology	J:110600
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	abnormal blood vessel morphology	J:70746
	abnormal eye development	J:70746
	abnormal optic vesicle formation	J:70746
	abnormal retina morphology	J:70746
	abnormal retina vasculature morphology	J:70746
	absent optic nerve	J:70746
	absent retina ganglion layer	J:70746
	decreased total retina thickness	J:70746
	thin retina inner nuclear layer	J:70746
	thin retina inner plexiform layer	J:70746
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina morphology	J:186563
	abnormal retina nerve fiber layer morphology	J:186563
	absent optic nerve	J:186563
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1	abnormal amacrine cell morphology	J:70746
	abnormal retina ganglion layer morphology	J:70746
	absent retina ganglion cell	J:70746
	increased retina cone cell number	J:70746
Atoh7^tm2Gan/Atoh7^tm2Gan involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	decreased retina ganglion cell number	J:167071
Atoh7^tm2Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal optic nerve morphology	J:67382
	abnormal retina ganglion cell morphology	J:67382
	abnormal retina morphology	J:67382
	abnormal retina nerve fiber layer morphology	J:67382
	decreased optic chiasm size	J:67382
	decreased retina ganglion cell number	J:67382
	decreased total retina thickness	J:67382
	normal reproductive system phenotype	J:67382
Atoh7^tm2Gan/Atoh7^tm2Gan Not Specified	abnormal rod electrophysiology	J:194077
Atoh7^tm3(cre)Gan/Atoh7^tm3(cre)Gan involves: 129S7/SvEvBrd * C57BL/6J	decreased retina ganglion cell number	J:86669, J:176668
	normal vision/eye phenotype	J:176668

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24