Atoh7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atoh7
atonal bHLH transcription factor 7
MGI:1355553

39 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atoh7^{tm1(Neurod1)Whk}/Atoh7^{tm2(Neurod4)Whk} involves: 129S6/SvEvTac * C57BL/6	abnormal optic nerve morphology	J:141248
	increased retina apoptosis	J:141248
	increased retina photoreceptor cell number	J:141248
	optic nerve hypoplasia	J:141248
	normal vision/eye phenotype	J:141248
Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7^{tm1.1(Ascl1)Nlbr} either: 129(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or B6.129S6(Cg)-Atoh7^{tm1.1(Ascl1)Nlbr} or (involves: 129S6/SvEvTac * C57BL/6J * CD-1 * FVB/N)	abnormal Muller cell morphology	J:203642
	abnormal retina bipolar cell morphology	J:203642
	abnormal retina vasculature morphology	J:203642
	absent optic nerve	J:203642
	decreased retina ganglion cell number	J:203642
	decreased total retina thickness	J:203642
	increased retina cone cell number	J:203642
Atoh7^tm1.1Xmu/Atoh7^tm1.1Xmu involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:151244
Atoh7^tm1Gan/Atoh7^{tm1(Neurod1)Whk} involves: 129S6/SvEvTac * C57BL/6	abnormal optic nerve morphology	J:141248
	decreased retina ganglion cell number	J:141248
	increased retina apoptosis	J:141248
	optic nerve hypoplasia	J:141248
Atoh7^tm1Gan/Atoh7^tm1Gan B6.Cg-Atoh7^tm1Gan	abnormal eye electrophysiology	J:135827
	abnormal Muller cell morphology	J:135827
	abnormal retina ganglion cell morphology	J:135827
	abnormal retina morphology	J:135827
	decreased retina ganglion cell number	J:135827
	increased retina apoptosis	J:135827
	optic nerve hypoplasia	J:135827
Atoh7^tm1Gan/Atoh7^tm1Gan involves: 129S/SvEv * C57BL/6J	increased amacrine cell number	J:67382
Atoh7^tm1Gan/Atoh7^tm1Gan involves: 129S/SvEv * C57BL/6J	normal reproductive system phenotype	J:67382
Atoh7^tm1Gan/Atoh7^tm1Gan Not Specified	abnormal retina cone bipolar cell morphology	J:119663
	absent optic nerve	J:141248
	absent retina ganglion cell	J:141248
	increased amacrine cell number	J:119663
Atoh7^tm1Gan/Atoh7^{tm2(Neurod4)Whk} involves: 129S6/SvEvTac * C57BL/6	absent optic nerve	J:141248
	decreased retina ganglion cell number	J:141248
Atoh7^tm1Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal retina ganglion cell morphology	J:67382
Atoh7^tm1Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal retina nerve fiber layer morphology	J:67382
Atoh7^tm1Gla/Atoh7^tm1Gla B6.129-Atoh7^tm1Gla	abnormal circardian behavior entrainment	J:99410
	abnormal eye electrophysiology	J:99410
	abnormal retina bipolar cell morphology	J:99410
	abnormal retina cone bipolar cell morphology	J:99410
	abnormal retina rod bipolar cell morphology	J:99410
	absent optic tract	J:99410
	decreased retina rod cell number	J:99410
	thin retina inner nuclear layer	J:99410
	thin retina inner plexiform layer	J:99410
	thin retina outer nuclear layer	J:99410
	thin retina outer plexiform layer	J:99410
Atoh7^tm1Gla/Atoh7^tm1Gla either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal cell cycle	J:110600
	abnormal eye development	J:110600
	abnormal retina cone cell morphology	J:110600
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	abnormal blood vessel morphology	J:70746
	abnormal eye development	J:70746
	abnormal optic vesicle formation	J:70746
	abnormal retina morphology	J:70746
	abnormal retina vasculature morphology	J:70746
	absent optic nerve	J:70746
	absent retina ganglion layer	J:70746
	decreased total retina thickness	J:70746
	thin retina inner nuclear layer	J:70746
	thin retina inner plexiform layer	J:70746
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina morphology	J:186563
	abnormal retina nerve fiber layer morphology	J:186563
	absent optic nerve	J:186563
Atoh7^tm1Gla/Atoh7^tm1Gla involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1	abnormal amacrine cell morphology	J:70746
	abnormal retina ganglion layer morphology	J:70746
	absent retina ganglion cell	J:70746
	increased retina cone cell number	J:70746
Atoh7^tm2Gan/Atoh7^tm2Gan involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	decreased retina ganglion cell number	J:167071
Atoh7^tm2Gan/Atoh7^tm2Gan involves: 129S/SvEv * C57BL/6J	abnormal optic nerve morphology	J:67382
	abnormal retina ganglion cell morphology	J:67382
	abnormal retina morphology	J:67382
	abnormal retina nerve fiber layer morphology	J:67382
	decreased optic chiasm size	J:67382
	decreased retina ganglion cell number	J:67382
	decreased total retina thickness	J:67382
	normal reproductive system phenotype	J:67382
Atoh7^tm2Gan/Atoh7^tm2Gan Not Specified	abnormal rod electrophysiology	J:194077
Atoh7^tm3(cre)Gan/Atoh7^tm3(cre)Gan involves: 129S7/SvEvBrd * C57BL/6J	decreased retina ganglion cell number	J:86669, J:176668
	normal vision/eye phenotype	J:176668

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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