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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tslp
thymic stromal lymphopoietin
MGI:1855696
72 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(KRT5-rtTA)1Glk/0
Tg(tetO/CMV-Tslp)#Sfz/0
C.Cg-Tg(KRT5-rtTA)1Glk Tg(tetO/CMV-Tslp)#Sfz 		abnormal B cell activation J:182756
decreased hematocrit J:182756
increased autoantibody level J:182756
increased B cell proliferation J:182756
increased circulating interleukin-4 level J:182756
increased susceptibility to autoimmune hemolytic anemia J:182756
Tg(KRT5-rtTA)1Glk/0
Tg(tetO/CMV-Tslp)#Sfz/0
involves: C3H * C57BL/6 * FVB/N 		abnormal cytokine level J:100506
abnormal lymph node morphology J:100506
acanthosis J:100506
conjunctivitis J:100506
decreased IgG2a level J:100506
dermatitis J:100506
dry skin J:100506
enlarged lymph nodes J:100506
enlarged spleen J:100506
epidermal spongiosis J:100506
hyperkeratosis J:100506
increased CD4-positive, alpha-beta T cell number J:100506
increased IgE level J:100506
increased IgG1 level J:100506
reddish skin J:100506
skin lesions J:100506
Tg(KRT14-Tslp)1Pcn/0
involves: C57BL/6 * SJL 		abnormal lymphocyte physiology J:102470
enlarged liver J:102470
enlarged spleen J:102470
increased immunoglobulin level J:102470
lymph node hyperplasia J:102470
mixed cellular infiltration to dermis J:102470
scaly ears J:102470
Tg(Lck-Tslp)1Chea/0
B6.Cg-Tg(Lck-Tslp)1Chea 		abnormal glomerular capillary endothelium morphology J:72982
abnormal glomerular capillary morphology J:72982
abnormal glomerular capillary thrombosis J:72982
abnormal glomerular endothelium fenestra morphology J:72982
abnormal glomerular mesangium morphology J:72982
albuminuria J:72982
decreased body weight J:72982
enlarged heart J:72982
enlarged lymph nodes J:72982
enlarged spleen J:72982
expanded mesangial matrix J:72982
glomerulonephritis J:72982
increased anti-nuclear antigen antibody level J:72982
increased blood urea nitrogen level J:72982
increased immunoglobulin level J:72982
increased liver weight J:72982
increased lung weight J:72982
increased renal glomerulus lobularity J:72982
increased spleen weight J:72982
liver inflammation J:72982
lung inflammation J:72982
mesangial cell interposition J:72982
podocyte foot process effacement J:72982
renal glomerular immunoglobulin deposits J:72982
spontaneous skin ulceration J:72982
Tslptm1(KOMP)Vlcg/Tslptm1(KOMP)Vlcg
involves: C57BL/6 * C57BL/6NTac 		abnormal airway responsiveness J:187770
abnormal immune system physiology J:187770
abnormal immunoglobulin level J:187770
abnormal T-helper 2 cell differentiation J:187770
decreased acute inflammation J:187770
decreased circulating interleukin-4 level J:187770
increased interferon-gamma secretion J:187770
respiratory system inflammation J:187770
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre)1Ipc/0
involves: 129 * C57BL/6 * SJL 		decreased eosinophil cell number J:146511
decreased IgE level J:146511
decreased lymphocyte cell number J:146511
decreased physiological sensitivity to xenobiotic J:146511
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129 * C57BL/6 * SJL 		decreased physiological sensitivity to xenobiotic J:146511
Tslptm1.2Pcn/Tslptm1.2Pcn
involves: 129 * C57BL/6 * SJL 		decreased physiological sensitivity to xenobiotic J:146511
Tslptm1Mak/Tslptm1Mak
B6.Cg-Tslptm1Mak 		colitis J:175844
normal digestive/alimentary phenotype J:175844
normal immune system phenotype J:175844
increased susceptibility to xenobiotic induced morbidity/mortality J:175844
weight loss J:175844
Tslptm1Sfz/Tslptm1Sfz
C.129(Cg)-Tslptm1Sfz 		normal immune system phenotype J:199558
normal integument phenotype J:199558
Tslptm1Sfz/Tslptm1Sfz
involves: 129 		abnormal interleukin secretion J:197193
abnormal T-helper 2 physiology J:197193
increased interleukin-5 secretion J:197193
increased interleukin-13 secretion J:197193
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory