Nucb2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nucb2
nucleobindin 2
MGI:1858179

12 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nucb2^{Gt(OST287865)Lex}/Nucb2^{Gt(OST287865)Lex} involves: 129S5/SvEvBrd * C57BL/6J	decreased heart rate	J:103485
	increased circulating alkaline phosphatase level	J:103485
Nucb2^tm1.1Vdix/Nucb2^tm1.1Vdix Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	normal growth/size/body region phenotype	J:270674
	impaired glucose tolerance	J:270674
	insulin resistance	J:270674
Nucb2^tm1.1Vdix/Nucb2^tm1.1Vdix Tg(Adipoq-cre/Esr1)1Evdr/0 involves: 129 C57BL/6	abnormal glucose homeostasis	J:270674
	normal growth/size/body region phenotype	J:270674
Nucb2^tm1.2Vdix/Nucb2^tm1.2Vdix involves: C57BL/6	abnormal glucose homeostasis	J:270674
	normal adipose tissue phenotype	J:270674
	normal growth/size/body region phenotype	J:270674
	normal homeostasis/metabolism phenotype	J:270674
	increased circulating free fatty acids level	J:270674
	increased hepatic glucose production	J:270674
	increased interleukin-1 beta secretion	J:270674
	increased tumor necrosis factor secretion	J:270674

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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