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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hnrnpu
heterogeneous nuclear ribonucleoprotein U
MGI:1858195
35 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hnrnpuem1Frk/Hnrnpu+
Not Specified 		abnormal brain wave pattern J:342579
abnormal motor capabilities/coordination/movement J:342579
behavioral developmental delay J:342579
decreased birth weight J:342579
decreased vocalization J:342579
impaired righting response J:342579
maximal tonic hindlimb extension seizures J:342579
normal nervous system phenotype J:342579
positive geotaxis J:342579
postnatal growth retardation J:342579
Hnrnpuem1Frk/Hnrnpuem1Frk
C57BL/6NJ-Hnrnpuem1Frk 		prenatal lethality, complete penetrance J:342579
HnrnpuGt(U3Neo)1Rul/HnrnpuGt(U3Neo)1Rul
either: B6.129S2-HnrnpuGt(U3Neo)1Rul or (involves: 129S2/SvPas * C57BL/6J) 		abnormal ectoderm development J:98861
abnormal extraembryonic tissue morphology J:98861
embryonic growth retardation J:98861
embryonic lethality during organogenesis, complete penetrance J:98861
failure of chorioallantoic fusion J:98861
Hnrnputm1.1Tman/Hnrnputm1.1Tman
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:223139
Hnrnputm1.1Tman/Hnrnputm1.1Tman
Tg(Ckmm-cre)5Khn/0
involves: 129S4/SvJaeSor * FVB 		abnormal heart echocardiography feature J:223139
abnormal I band morphology J:223139
abnormal myocardial fiber morphology J:223139
abnormal myocardial fiber physiology J:223139
abnormal sarcomere morphology J:223139
congestive heart failure J:223139
decreased cardiac muscle relaxation J:223139
decreased heart ventricle muscle contractility J:223139
decreased mitochondrial number J:223139
decreased myocardial fiber number J:223139
dilated cardiomyopathy J:223139
dilated heart left ventricle J:223139
dilated heart ventricle J:223139
increased cardiomyocyte apoptosis J:223139
increased myocardial fiber size J:223139
postnatal lethality, complete penetrance J:223139
thin interventricular septum J:223139
thin ventricular wall J:223139
Hnrnputm1.1Tman/Hnrnputm1.1Tman
Tg(Myh6-cre)2182Mds/0
involves: 129S4/SvJaeSor * FVB/N 		congestive heart failure J:223139
dilated cardiomyopathy J:223139
postnatal lethality, complete penetrance J:223139
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory