Rab11a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rab11a
RAB11A, member RAS oncogene family
MGI:1858202

34 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae	abnormal intestinal epithelium morphology	J:215917
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Tg(Vil1-cre)997Gum/0 involves: 129S4/SvJae * C57BL/6J * SJL	abnormal crypts of Lieberkuhn morphology	J:215917
	abnormal cytokine secretion	J:215917
	abnormal digestive system physiology	J:215917
	abnormal intestinal epithelium morphology	J:215917
	abnormal intestinal goblet cell morphology	J:215917
	abnormal intestine morphology	J:215917
	abnormal intestine physiology	J:215917, J:278932
	abnormal small intestinal crypt cell physiology	J:278932
	abnormal small intestinal crypt cell proliferation	J:215917
	abnormal small intestinal villus morphology	J:215917
	decreased body size	J:215917
	decreased colon length	J:215917
	decreased small intestinal villus size	J:215917
	increased cytokine level	J:278932
	increased incidence of tumors by chemical induction	J:278932
	increased interleukin-1 beta secretion	J:215917
	increased interleukin-6 secretion	J:215917
	increased intestinal adenoma incidence	J:278932
	increased susceptibility to induced morbidity/mortality	J:278932
	intestinal inflammation	J:215917
	postnatal lethality, incomplete penetrance	J:215917
	premature death	J:215917
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Tg(Vil1-cre/ERT2)23Syr/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	abnormal small intestinal crypt cell proliferation	J:215917, J:278932
	increased interleukin-6 secretion	J:215917
Rab11a^{tm1b(KOMP)Wtsi}/Rab11a⁺ B6N(Cg)-Rab11a^{tm1b(KOMP)Wtsi}/J	improved glucose tolerance	J:211773
	persistence of hyaloid vascular system	J:211773
Rab11a^{tm1b(KOMP)Wtsi}/Rab11a^{tm1b(KOMP)Wtsi} B6N(Cg)-Rab11a^{tm1b(KOMP)Wtsi}/J	abnormal egg cylinder morphology	J:279207
	absent head fold	J:279207
	absent primitive node	J:279207
	decreased embryo size	J:279207
	embryonic growth arrest	J:279207
	embryonic lethality between implantation and placentation, complete penetrance	J:279207
	embryonic lethality prior to organogenesis	J:211773
	failure of primitive streak formation	J:279207
	failure to gastrulate	J:279207
	preweaning lethality, complete penetrance	J:211773

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