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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k14
mitogen-activated protein kinase kinase kinase 14
MGI:1858204
90 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
involves: 129P2/OlaHsd * C57BL/6 		enlarged lymph nodes J:139293
enlarged spleen J:139293
increased marginal zone B cell number J:139293
increased mature B cell number J:139293
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
involves: 129P2/OlaHsd * C57BL/6 		abnormal Peyer's patch morphology J:139293
abnormal spleen B cell follicle morphology J:139293
decreased B-1 B cell number J:139293
enlarged lymph nodes J:139293
enlarged spleen J:139293
increased mature B cell number J:139293
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Map3k14tm1.1Gne/Map3k14tm1.1Gne
B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte 		abnormal immunoglobulin level J:240453
decreased B cell number J:240453
decreased B cell proliferation J:240453
decreased germinal center B cell number J:240453
decreased IgA level J:240453
decreased IgG1 level J:240453
decreased IgM level J:240453
decreased Peyer's patch number J:240453
normal immune system phenotype J:240453
Map3k14aly/Map3k14aly
C57BL/6J-Map3k14aly 		absent lymph nodes J:16865
increased susceptibility to infection J:16865
premature death J:16865
Map3k14aly/Map3k14aly
involves: AEJ/GnRk * C57BL/6J 		abnormal immune system morphology J:54529
abnormal lymphocyte morphology J:16865
abnormal lymphopoiesis J:16865
abnormal mammary gland development J:16865
abnormal spleen primary B follicle morphology J:54529
absent follicular dendritic cells J:54529
absent lymph nodes J:16865, J:54529
absent Peyer's patches J:16865, J:54529
absent spleen marginal zone J:54529
absent thymus corticomedullary boundary J:16865, J:54529
decreased B cell number J:54529
decreased IgA level J:16865, J:54529
decreased IgG level J:16865, J:54529
decreased IgM level J:16865, J:54529
decreased spleen B cell follicle number J:16865
increased length of allograft survival J:16865
normal mortality/aging J:16865
Map3k14aly/Map3k14aly
involves: C57BL/6J 		abnormal bile duct morphology J:48224
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:87993, J:128211
abnormal dendritic cell antigen presentation J:128211
abnormal dendritic cell physiology J:128211
abnormal hepatobiliary system morphology J:48224
abnormal immune system morphology J:147681
abnormal immune system physiology J:147681
abnormal intestinal epithelium morphology J:126867
abnormal intestinal goblet cell morphology J:135748
abnormal mammary fat pad morphology J:117313
abnormal mammary gland development J:117313
abnormal NK T cell morphology J:120659
abnormal salivary gland morphology J:38580, J:48224
abnormal T cell activation J:38580
abnormal thymus corticomedullary boundary morphology J:87993
abnormal thymus medulla morphology J:87993
absent Peyer's patches J:120659
bile duct hyperplasia J:48224
bile duct inflammation J:48224
bile duct proliferation J:48224
decreased circulating interferon-gamma level J:120659
decreased circulating interleukin-4 level J:120659
decreased dendritic cell number J:128211
decreased IgE level J:135748
decreased mammary fat pad weight J:117313
decreased mast cell number J:135748
decreased NK T cell number J:120659
decreased regulatory T cell number J:128211
dilated bile duct J:48224
increased eosinophil cell number J:135748
increased inflammatory response J:38580, J:48224
increased susceptibility to parasitic infection J:135748
kidney inflammation J:38580
lacrimal gland inflammation J:38580
liver inflammation J:48224
lung inflammation J:48224
pancreas inflammation J:48224
small thymus J:147681
thymus cyst J:147681
Map3k14m1Btlr/Map3k14m1Btlr
C57BL/6J-Map3k14m1Btlr 		abnormal B cell activation J:152065
absent lymph nodes J:152065
arrested B cell differentiation J:152065
decreased B cell number J:152065
decreased IgG level J:152065
Map3k14m1Btlr/Map3k14m1Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
arrested B cell differentiation J:185495
decreased IgG level J:185495
Map3k14tm1.1Gne/Map3k14tm1.1Gne
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac 		decreased B cell number J:280549
Map3k14tm1.2Gne/Map3k14tm1.2Gne
B6(Cg)-Map3k14tm1.2Gne 		abnormal B cell physiology J:240453
abnormal spleen marginal zone morphology J:240453
abnormal thymus cell ratio J:240453
absent inguinal lymph nodes J:240453
absent Peyer's patches J:240453
absent popliteal lymph nodes J:240453
decreased B cell number J:240453
decreased B-2 B cell number J:240453
decreased follicular B cell number J:240453
decreased germinal center B cell number J:240453
decreased IgA level J:240453
decreased marginal zone B cell number J:240453
decreased transitional stage T1 B cell number J:240453
decreased transitional stage T2 B cell number J:240453
small axillary lymph nodes J:240453
small brachial lymph nodes J:240453
Map3k14tm1Rds/Map3k14tm1Rds
involves: 129 		abnormal class switch recombination J:188560
Map3k14tm1Rds/Map3k14tm1Rds
involves: 129/Sv * C57BL/6 		abnormal spleen morphology J:68125
abnormal thymus morphology J:68125
absent axillary lymph nodes J:68125
absent cervical lymph nodes J:68125
absent inguinal lymph nodes J:68125
absent lymph nodes J:68125
absent mesenteric lymph nodes J:68125
absent Peyer's patches J:68125
absent popliteal lymph nodes J:68125
decreased IgA level J:68125
decreased IgG2b level J:68125
decreased immunoglobulin level J:68125
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory