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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Clpp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
MGI:1858213
63 phenotypes from 3 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
ClppGt(IST11134F10)Tigm/ClppGt(IST11134F10)Tigm
involves: C57BL/6N 		abnormal cellular respiration J:203140
abnormal granulosa cell morphology J:203140
abnormal oogenesis J:203140
abnormal seminiferous tubule epithelium morphology J:203140
abnormal T cell activation J:203140
arrest of spermatogenesis J:203140
azoospermia J:203140
decreased body length J:203140
decreased corpora lutea number J:203140
decreased fibroblast proliferation J:203140
decreased locomotor activity J:203140
decreased startle reflex J:203140
decreased susceptibility to weight gain J:203140
decreased vertical activity J:203140
dermatitis J:203140
disorganized mitochondrial cristae J:203140
early cellular replicative senescence J:203140
female infertility J:203140
increased granulosa cell apoptosis J:203140
increased mitochondrial DNA content J:203140
increased mitochondrial size J:203140
male infertility J:203140
premature death J:203140
preweaning lethality, incomplete penetrance J:203140
small ovary J:203140
small testis J:203140
ClppGt(IST13563G11)Tigm/ClppGt(IST13563G11)Tigm
involves: C57BL/6N 		abnormal cellular respiration J:203140
abnormal granulosa cell morphology J:203140
abnormal oogenesis J:203140
abnormal seminiferous tubule epithelium morphology J:203140
abnormal T cell activation J:203140
arrest of spermatogenesis J:203140
azoospermia J:203140
decreased body length J:203140
decreased corpora lutea number J:203140
decreased fibroblast proliferation J:203140
decreased locomotor activity J:203140
decreased startle reflex J:203140
decreased susceptibility to weight gain J:203140
decreased vertical activity J:203140
dermatitis J:203140
disorganized mitochondrial cristae J:203140
early cellular replicative senescence J:203140
female infertility J:203140
increased embryonic tissue cell apoptosis J:203140
increased mitochondrial DNA content J:203140
increased mitochondrial size J:203140
male infertility J:203140
premature death J:203140
preweaning lethality, incomplete penetrance J:203140
small ovary J:203140
small testis J:203140
Clpptm1a(EUCOMM)Wtsi/Clpptm1a(EUCOMM)Wtsi
C57BL/6N-Clpptm1a(EUCOMM)Wtsi/Wtsi 		abnormal auditory brainstem response J:211773
abnormal bone structure J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased CD4-positive NK T cell number J:211773
decreased circulating fructosamine level J:211773
decreased circulating glucose level J:211773
decreased effector memory CD8-positive, alpha-beta T cell number J:211773
decreased gamma-delta T cell number J:211773
decreased lean body mass J:211773
decreased memory-marker CD4-negative NK T cell number J:211773
decreased memory-marker CD4-positive NK T cell number J:211773
decreased NK T cell number J:211773
decreased red blood cell distribution width J:211773
decreased total body fat amount J:211773
female infertility J:211773
increased B cell number J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating bilirubin level J:211773
increased circulating cholesterol level J:211773
increased circulating glycerol level J:211773
increased circulating iron level J:211773
increased circulating serum albumin level J:211773
increased hematocrit J:211773
increased hemoglobin content J:211773
increased KLRG1-positive NK cell number J:211773
increased lean body mass J:211773
increased leukocyte cell number J:211773
increased Ly6C high monocyte number J:211773
increased Ly6C low monocyte number J:211773
increased mature B cell number J:211773
increased mean corpuscular hemoglobin J:211773
increased monocyte cell number J:211773
increased total body fat amount J:211773
male infertility J:211773
thrombocytopenia J:211773
tremors J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory