Ppm1d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
MGI:1858214

22 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppm1d^tm1Lad/Ppm1d^tm1Lad involves: 129S7/SvEvBrd	decreased pancreatic beta cell proliferation	J:151980
Ppm1d^tm1Lad/Ppm1d^tm1Lad involves: 129S7/SvEvBrd	impaired glucose tolerance	J:151980
Ppm1d^tm1Lad/Ppm1d^tm1Lad involves: 129S7/SvEvBrd * C57BL/6	abnormal epididymis morphology	J:74284
	chronic inflammation	J:74284
	decreased B cell proliferation	J:74284
	decreased body size	J:74284
	decreased CD8-positive, alpha-beta T cell number	J:74284
	decreased T cell proliferation	J:74284
	enlarged spleen	J:74284
	increased CD4-positive, alpha-beta T cell number	J:74284
	increased susceptibility to Orthomyxoviridae infection	J:74284
	lymphoid hyperplasia	J:74284
	male infertility	J:74284
	myeloid hyperplasia	J:74284
	oligozoospermia	J:74284
	premature death	J:74284
	prenatal lethality, incomplete penetrance	J:74284
	seminiferous tubule degeneration	J:74284
	skin lesions	J:74284
	small testis	J:74284
	small thymus	J:74284
	spleen hyperplasia	J:74284

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24