Ctps1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ctps1
cytidine 5'-triphosphate synthase 1
MGI:1858304

41 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ctps1^em1(IMPC)Tcp/Ctps1⁺ C57BL/6N-Ctps1^em1(IMPC)Tcp/Tcp	abnormal skin morphology	J:211773
	enlarged lymph nodes	J:211773
	enlarged urinary bladder	J:211773
Ctps1^em1(IMPC)Tcp/Ctps1^em1(IMPC)Tcp C57BL/6N-Ctps1^em1(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Ctps1^em1Slat/Ctps1^em1Slat C57BL/6J-Ctps1^em1Slat	no abnormal phenotype detected	J:348981
Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}/0 B6.Cg-Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}	abnormal spleen morphology	J:348981
	anemia	J:348981
	decreased B cell number	J:348981
	decreased body size	J:348981
	decreased bone marrow cell number	J:348981
	decreased double-positive T cell number	J:348981
	decreased hematopoietic stem cell number	J:348981
	decreased megakaryocyte-erythroid progenitor cell number	J:348981
	decreased NK cell number	J:348981
	decreased T cell number	J:348981
	decreased T cell proliferation	J:348981
	increased CD4-positive, alpha-beta T cell number	J:348981
	increased CD8-positive, alpha-beta T cell number	J:348981
	premature death	J:348981
	prenatal lethality, incomplete penetrance	J:348981
	small thymus	J:348981
	thymus hypoplasia	J:348981
Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ B6.Cg-Ctps1^{tm1c(KOMP)Wtsi} Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}	abnormal intestinal epithelium morphology	J:348981
	abnormal small intestinal villus morphology	J:348981
	abnormal small intestine crypts of Lieberkuhn morphology	J:348981
	abnormal spleen morphology	J:348981
	abnormal thymus physiology	J:348981
	decreased erythrocyte cell number	J:348981
	decreased germinal center B cell number	J:348981
	decreased hemoglobin content	J:348981
	decreased IgM level	J:348981
	decreased lymphocyte cell number	J:348981
	decreased small intestinal villus height	J:348981
	decreased T cell proliferation	J:348981
	decreased T follicular helper cell number	J:348981
	impaired humoral immune response	J:348981
	increased CD8-positive, alpha-beta T cell number	J:348981
	reticulocytopenia	J:348981
	small thymus	J:348981
	thymus hypoplasia	J:348981
	weight loss	J:348981
Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/0 involves: 129S/Sv * C57BL/6 * DBA/2	decreased effector memory T-helper cell number	J:348981
	decreased T cell proliferation	J:348981
	increased CD8-positive, naive alpha-beta T cell number	J:348981
Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan/0 B6(129S4)-Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan	decreased T cell proliferation	J:348981
Ctps1^{tm1d(KOMP)Wtsi}/Ctps1^{tm1d(KOMP)Wtsi} B6(Cg)-Ctps1^{tm1d(KOMP)Wtsi}	embryonic growth arrest	J:348981
	embryonic lethality prior to organogenesis, complete penetrance	J:348981

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