Stk39 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stk39
serine/threonine kinase 39
MGI:1858416

41 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stk39^Rnl5/? C57BL/6J-Stk39^Rnl5/Pgn	albuminuria	J:82961
Stk39^tm1.1Arte/Stk39⁺ involves: 129S/SvEvBrd * C57BL/6J	decreased mean systemic arterial blood pressure	J:191566
Stk39^tm1.1Arte/Stk39^tm1.1Arte involves: 129S/SvEvBrd * C57BL/6J	decreased circulating magnesium level	J:191566
	decreased mean systemic arterial blood pressure	J:191566
	decreased urine calcium level	J:191566
	normal homeostasis/metabolism phenotype	J:191566
	hypokalemia	J:191566
	increased urine potassium level	J:191566
	increased urine sodium level	J:191566
Stk39^tm1.1Pawe/Stk39^tm1.1Pawe involves: 129S6/SvEvTac * C57BL/6J	prenatal lethality, complete penetrance	J:287773
Stk39^tm1.2Slin/Stk39⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal homeostasis/metabolism phenotype	J:165706
	hypotension	J:165706
Stk39^tm1.2Slin/Stk39^tm1.2Slin involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal blood homeostasis	J:165706
	decreased circulating magnesium level	J:165706
	decreased circulating potassium level	J:165706
	decreased urine calcium level	J:165706
	decreased urine chloride ion level	J:165706
	decreased urine sodium level	J:165706
	hypotension	J:165706
	increased circulating aldosterone level	J:165706
	increased urine magnesium level	J:165706
	increased urine potassium level	J:165706
Stk39^tm1Dlp/Stk39^tm1Dlp involves: 129S6/SvEvTac * C57BL/6	abnormal neuron physiology	J:150513
Stk39^tm1Dlp/Stk39^tm1Dlp involves: 129S6/SvEvTac * C57BL/6	reduced fertility	J:150513
Stk39^tm1Pawe/Stk39^tm1Pawe involves: 129S6/SvEvTac * C57BL/6J	alkalosis	J:287773
	hypokalemia	J:287773
	increased blood urea nitrogen level	J:287773
	increased hematocrit	J:287773
Stk39^tm1Pawe/Stk39^tm1Pawe Pvalb^tm1(cre)Arbr/Pvalb⁺ B6.129-Stk39^tm1Pawe Pvalb^tm1(cre)Arbr	abnormal kidney physiology	J:287773
	abnormal nephron morphology	J:287773
	decreased blood urea nitrogen level	J:287773
	decreased hematocrit	J:287773
	decreased renin activity	J:287773
	decreased urine potassium level	J:287773
	hyperkalemia	J:287773
	hypertension	J:287773
	increased circulating chloride level	J:287773
	metabolic acidosis	J:287773
	salt-sensitive hypertension	J:287773
Stk39^tm2.1Arte/Stk39^tm2.1Arte involves: C57BL/6J	abnormal artery morphology	J:224087
	abnormal heart echocardiography feature	J:224087
	decreased circulating magnesium level	J:224087
	decreased circulating potassium level	J:224087
	decreased heart left ventricle weight	J:224087
	decreased heart rate	J:224087
	decreased mean systemic arterial blood pressure	J:224087
	decreased systemic arterial diastolic blood pressure	J:224087
	decreased systemic arterial systolic blood pressure	J:224087
	decreased systemic vascular resistance	J:224087
	decreased urine calcium level	J:224087
	decreased vasoconstriction	J:224087
	increased urine sodium level	J:224087
	normal renal/urinary system phenotype	J:224087

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24