Stk39 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stk39
serine/threonine kinase 39
MGI:1858416

41 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stk39^Rnl5/? C57BL/6J-Stk39^Rnl5/Pgn	albuminuria	J:82961
Stk39^tm1.1Arte/Stk39⁺ involves: 129S/SvEvBrd * C57BL/6J	decreased mean systemic arterial blood pressure	J:191566
Stk39^tm1.1Arte/Stk39^tm1.1Arte involves: 129S/SvEvBrd * C57BL/6J	decreased circulating magnesium level	J:191566
	decreased mean systemic arterial blood pressure	J:191566
	decreased urine calcium level	J:191566
	normal homeostasis/metabolism phenotype	J:191566
	hypokalemia	J:191566
	increased urine potassium level	J:191566
	increased urine sodium level	J:191566
Stk39^tm1.1Pawe/Stk39^tm1.1Pawe involves: 129S6/SvEvTac * C57BL/6J	prenatal lethality, complete penetrance	J:287773
Stk39^tm1.2Slin/Stk39⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal homeostasis/metabolism phenotype	J:165706
	hypotension	J:165706
Stk39^tm1.2Slin/Stk39^tm1.2Slin involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal blood homeostasis	J:165706
	decreased circulating magnesium level	J:165706
	decreased circulating potassium level	J:165706
	decreased urine calcium level	J:165706
	decreased urine chloride ion level	J:165706
	decreased urine sodium level	J:165706
	hypotension	J:165706
	increased circulating aldosterone level	J:165706
	increased urine magnesium level	J:165706
	increased urine potassium level	J:165706
Stk39^tm1Dlp/Stk39^tm1Dlp involves: 129S6/SvEvTac * C57BL/6	abnormal neuron physiology	J:150513
Stk39^tm1Dlp/Stk39^tm1Dlp involves: 129S6/SvEvTac * C57BL/6	reduced fertility	J:150513
Stk39^tm1Pawe/Stk39^tm1Pawe involves: 129S6/SvEvTac * C57BL/6J	alkalosis	J:287773
	hypokalemia	J:287773
	increased blood urea nitrogen level	J:287773
	increased hematocrit	J:287773
Stk39^tm1Pawe/Stk39^tm1Pawe Pvalb^tm1(cre)Arbr/Pvalb⁺ B6.129-Stk39^tm1Pawe Pvalb^tm1(cre)Arbr	abnormal kidney physiology	J:287773
	abnormal nephron morphology	J:287773
	decreased blood urea nitrogen level	J:287773
	decreased hematocrit	J:287773
	decreased renin activity	J:287773
	decreased urine potassium level	J:287773
	hyperkalemia	J:287773
	hypertension	J:287773
	increased circulating chloride level	J:287773
	metabolic acidosis	J:287773
	salt-sensitive hypertension	J:287773
Stk39^tm2.1Arte/Stk39^tm2.1Arte involves: C57BL/6J	abnormal artery morphology	J:224087
	abnormal heart echocardiography feature	J:224087
	decreased circulating magnesium level	J:224087
	decreased circulating potassium level	J:224087
	decreased heart left ventricle weight	J:224087
	decreased heart rate	J:224087
	decreased mean systemic arterial blood pressure	J:224087
	decreased systemic arterial diastolic blood pressure	J:224087
	decreased systemic arterial systolic blood pressure	J:224087
	decreased systemic vascular resistance	J:224087
	decreased urine calcium level	J:224087
	decreased vasoconstriction	J:224087
	increased urine sodium level	J:224087
	normal renal/urinary system phenotype	J:224087

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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