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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sec61a1
SEC61 translocon subunit alpha 1
MGI:1858417
26 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sec61a1m1Gek/Sec61a1+
C57BL/6J-Sec61a1m1Gek 		decreased circulating insulin level J:164159
hyperglycemia J:164159
Sec61a1m1Gek/Sec61a1m1Gek
C57BL/6J-Sec61a1m1Gek 		abnormal glucose homeostasis J:164159
abnormal pancreatic beta cell morphology J:164159
abnormal pancreatic beta cell physiology J:164159
abnormal pancreatic delta cell morphology J:164159
decreased body size J:164159
decreased circulating insulin level J:164159
decreased lean body mass J:164159
decreased pancreatic beta cell number J:164159
decreased skeletal muscle mass J:164159
decreased total body fat amount J:164159
enlarged liver J:164159
hepatic steatosis J:164159
hyperglycemia J:164159
impaired glucose tolerance J:164159
increased circulating cholesterol level J:164159
increased circulating glucagon level J:164159
increased circulating triglyceride level J:164159
increased hepatocyte apoptosis J:164159
increased hepatocyte proliferation J:164159
increased pancreatic alpha cell number J:164159
increased pancreatic beta cell apoptosis J:164159
increased pancreatic delta cell number J:164159
liver cirrhosis J:164159
pale liver J:164159
Sec61a1m1Gek/Sec61a1m1Gek
Tg(Ins2-Sec61a1)#Gek/0
C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek 		abnormal pancreatic beta cell morphology J:164159
decreased body size J:164159
decreased lean body mass J:164159
decreased total body fat amount J:164159
normal endocrine/exocrine gland phenotype J:164159
enlarged liver J:164159
hepatic steatosis J:164159
normal homeostasis/metabolism phenotype J:164159
liver cirrhosis J:164159
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory