Rfx5 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rfx5
regulatory factor X, 5 (influences HLA class II expression)
MGI:1858421

11 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rfx5^tm1.1Ifo/Rfx5^tm1.1Ifo involves: 129 * C57BL/6	abnormal B lymphocyte antigen presentation	J:67941
	abnormal dendritic cell morphology	J:67941
	abnormal Kupffer cell morphology	J:67941
	abnormal level of surface class II molecules	J:67941
	abnormal MHC II cell surface expression on macrophages	J:67941
	abnormal thymus cortex morphology	J:67941
	decreased CD4-positive, alpha-beta T cell number	J:67941
	decreased IgG1 level	J:67941
	decreased IgM level	J:67941
	decreased single-positive T cell number	J:67941
Rfx5^tm1Ifo/Rfx5^tm1.1Ifo Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6 * C.B-20	abnormal MHC II cell surface expression on macrophages	J:67924
Rfx5^tm1Ifo/Rfx5^tm1Ifo involves: 129P2/OlaHsd * C57BL/6J	normal immune system phenotype	J:282535

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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