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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Icos
inducible T cell co-stimulator
MGI:1858745
55 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Icostm1.1Wks/Icostm1.1Wks
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell number J:155586
abnormal B cell physiology J:155586
abnormal B cell selection J:155586
abnormal class switch recombination J:155586
abnormal immune system physiology J:155586
abnormal Peyer's patch germinal center morphology J:155586
abnormal spleen morphology J:155586
decreased CD4-positive, alpha-beta T cell number J:155586
decreased IgA level J:155586
decreased IgG1 level J:155586
decreased IgG2b level J:155586
decreased IgG2c level J:155586
decreased interleukin-4 secretion J:155586
decreased interleukin-21 secretion J:155586
decreased spleen germinal center number J:155586
small Peyer's patches J:155586
Icostm1Dgry/Icostm1Dgry
B6.129P2-Icostm1Dgry 		abnormal CD4-positive, alpha-beta T cell physiology J:123477
abnormal immune system physiology J:123477
abnormal interleukin secretion J:123477
abnormal leukocyte cell number J:123477
abnormal memory B cell number J:123477
abnormal response to infection J:123477
abnormal T cell physiology J:123477
decreased germinal center B cell number J:123477
decreased IgG level J:123477
decreased interleukin-4 secretion J:123477
decreased interleukin-5 secretion J:123477
decreased plasma cell number J:123477
increased plasma cell number J:123477
Icostm1Flv/Icos+
NOD.129S1-Icostm1Flv 		decreased pancreatic islet number J:131529
insulitis J:131529
Icostm1Flv/Icostm1Flv
involves: 129/Sv * C57BL/6 		abnormal immunoglobulin level J:87123
abnormal interferon level J:87123
abnormal interleukin level J:87123
abnormal T-helper 2 physiology J:87123
decreased IgE level J:87123
decreased IgG1 level J:87123
normal immune system phenotype J:87123
increased susceptibility to experimental autoimmune encephalomyelitis J:87123
small lymph nodes J:87123
Icostm1Flv/Icostm1Flv
involves: 129S1/Sv 		abnormal cytokine secretion J:112600
Icostm1Flv/Icostm1Flv
NOD.129S1-Icostm1Flv 		decreased anti-insulin autoantibody level J:131529
decreased autoantibody level J:131529
decreased IgG level J:131529
decreased interferon-gamma secretion J:131529
decreased susceptibility to autoimmune diabetes J:131529
decreased T cell number J:131529
normal endocrine/exocrine gland phenotype J:131529
normal immune system phenotype J:131529
insulitis J:131529
Icostm1Mak/Icostm1Mak
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell number J:155586
abnormal B cell physiology J:66702
abnormal class switch recombination J:66702
abnormal immune system physiology J:66702
abnormal Peyer's patch germinal center morphology J:155586
abnormal spleen morphology J:66702
abnormal T cell physiology J:66702
decreased CD4-positive, alpha-beta T cell number J:155586
decreased IgA level J:155586
decreased IgE level J:66702
decreased IgG1 level J:66702, J:155586
decreased IgG2b level J:155586
decreased IgG2c level J:155586
decreased interleukin-21 secretion J:155586
decreased spleen germinal center number J:66702, J:155586
decreased spleen germinal center size J:66702
decreased T cell proliferation J:66702
small Peyer's patches J:155586
Icostm1Shr/Icostm1Shr
Not Specified 		abnormal CD4-positive, alpha-beta T cell physiology J:87124
abnormal immunoglobulin level J:87124
abnormal interleukin level J:87124
abnormal spleen germinal center morphology J:87124
abnormal T cell differentiation J:87124
decreased IgE level J:87124
decreased IgG1 level J:87124
decreased IgG2a level J:87124
decreased IgG level J:87124
increased IgG3 level J:87124
Icostm1Tkan/Icostm1Tkan
involves: 129S7/SvEvBrd * C57BL/6 		abnormal NK cell physiology J:95353
abnormal Peyer's patch germinal center morphology J:95728
abnormal small intestine morphology J:95728
decreased circulating interferon-gamma level J:95353
decreased circulating interleukin-4 level J:95353
small Peyer's patches J:95728
Icostm2b(EUCOMM)Wtsi/Icostm2b(EUCOMM)Wtsi
C57BL/6N-Icostm2b(EUCOMM)Wtsi/Orl 		short tibia J:211773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory