Spast Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spast
spastin
MGI:1858896

35 phenotypes from 7 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spast^M1Gri/Spast⁺ B6.C-Spast^M1Gri	abnormal axon morphology	J:148877
Spast^M1Gri/Spast⁺ B6.C-Spast^M1Gri	abnormal axonal transport	J:148877
Spast^M1Gri/Spast^M1Gri B6.C-Spast^M1Gri	abnormal axon morphology	J:148877
	abnormal axonal transport	J:148877
	abnormal gait	J:148877
Spast^tm1.1Evre/Spast^tm1.1Evre C57BL/6-Spast^tm1.1Evre	abnormal axon morphology	J:253467
	abnormal gait	J:253467
	decreased body weight	J:253467
	long stride length	J:253467
Spast^tm1.1Jme/Spast⁺ involves: C57BL/6J	abnormal axon morphology	J:117740
Spast^tm1.1Jme/Spast^tm1.1Jme involves: C57BL/6J	abnormal axon morphology	J:117740
	abnormal gait	J:117740
	infertility	J:117740
	short stride length	J:117740
Spast^{tm1a(KOMP)Wtsi}/Spast^{tm1a(KOMP)Wtsi} involves: C57BL/6N	abnormal acrosome assembly	J:334562
	abnormal acrosome morphology	J:334562
	abnormal double-strand DNA break repair	J:334562
	abnormal male meiosis	J:334562
	abnormal manchette assembly	J:334562
	abnormal manchette disassembly	J:334562
	abnormal manchette morphology	J:334562
	abnormal meiotic spindle morphology	J:334562
	abnormal seminiferous tubule epithelium morphology	J:334562
	abnormal sperm nucleus morphology	J:334562
	abnormal spermatid morphology	J:334562
	abnormal spermatogenesis	J:334562
	abnormal spermiogenesis	J:334562
	aneuploidy	J:334562
	arrest of male meiosis	J:334562
	azoospermia	J:334562
	decreased testis weight	J:334562
	ectopic manchette	J:334562
	elongated manchette	J:334562
	increased male germ cell apoptosis	J:334562
	male infertility	J:334562
	normal reproductive system phenotype	J:334562
	seminiferous tubule degeneration	J:334562
	small testis	J:334562
Spast^{tm1b(KOMP)Wtsi}/Spast^{tm1b(KOMP)Wtsi} C57BL/6N-Spast^{tm1b(KOMP)Wtsi}/Tcp	abnormal brain morphology	J:211773
	hydrocephaly	J:211773
Spast^tm1Jfnk/Spast⁺ involves: 129S1/Sv * 129X1/SvJ	impaired coordination	J:94077
Spast^tm1Jfnk/Spast^tm1Jfnk involves: 129S1/Sv * 129X1/SvJ	impaired coordination	J:94077
Spast^tm1Jme/Spast^tm1Jme involves: C57BL/6J	no abnormal phenotype detected	J:117740

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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