Irx5 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irx5
Iroquois homeobox 5
MGI:1859086

12 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irx3^tm3.1Hui/Irx3^tm3.1Hui Irx5^tm3Hui/Irx5^tm3Hui Not Specified	abnormal cardiac outflow tract development	J:189007
	abnormal heart development	J:189007
	abnormal heart septum morphology	J:189007
	abnormal interatrial septum morphology	J:189007
	atrial septal defect	J:189007
	atrioventricular septal defect	J:189007
	double outlet right ventricle	J:189007
	lethality throughout fetal growth and development, complete penetrance	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ involves: FVB	prolonged PR interval	J:189007
	prolonged QRS complex duration	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: C57BL/6J * CBA/J	normal cardiovascular system phenotype	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Isl1^tm1(cre)Sev/Isl1⁺ involves: 129S/Sv	abnormal cardiac outflow tract development	J:189007
	abnormal interatrial septum morphology	J:189007
	atrial septal defect	J:189007
	atrioventricular septal defect	J:189007
	double outlet right ventricle	J:189007
	persistent truncus arteriosus	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Mef2c-cre)#Blk/0 Not Specified	abnormal cardiac outflow tract development	J:189007
	double outlet right ventricle	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Nkx2-5-cre)9Eno/0 Not Specified	normal cardiovascular system phenotype	J:189007
Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * SJL	abnormal cardiac outflow tract development	J:189007
	atrial septal defect	J:189007
	atrioventricular septal defect	J:189007
	double outlet right ventricle	J:189007

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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