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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pla2g6
phospholipase A2, group VI
MGI:1859152
53 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pla2g6m1J/Pla2g6m1J
C3H/HeJ-Pla2g6m1J 		abnormal astrocyte physiology J:183152
decreased grip strength J:183152
neurodegeneration J:183152
premature death J:183152
tremors J:183152
weight loss J:183152
Pla2g6m1Sein/Pla2g6m1Sein
C57BL/6JJcl-Pla2g6m1Sein 		abnormal astrocyte physiology J:183152
abnormal axon morphology J:153195
abnormal brain morphology J:153195
abnormal brain white matter morphology J:153195
abnormal brainstem morphology J:153195
abnormal motor capabilities/coordination/movement J:155328
abnormal motor coordination/balance J:153195
abnormal nervous system morphology J:153195, J:155328
abnormal spinal cord morphology J:153195
ataxia J:155328
axonal dystrophy J:183152
decreased double-positive T cell number J:155328
decreased grip strength J:155328
hindlimb paralysis J:155328
muscular atrophy J:153195
neurodegeneration J:183152
premature death J:153195, J:155328
skeletal muscle atrophy J:155328
weight loss J:155328
Pla2g6tm1.1Hlw/Pla2g6tm1.1Hlw
involves: 129 * C57BL/6J 		abnormal mitochondrial crista morphology J:317126
abnormal mitochondrial morphology J:317126
abnormal mitochondrial physiology J:317126
abnormal mitophagy J:317126
abnormal substantia nigra pars compacta morphology J:317126
abnormal synaptic bouton morphology J:317126
bradykinesia J:317126
decreased locomotor activity J:317126
decreased mitochondrial size J:317126
decreased vertical activity J:317126
impaired coordination J:317126
increased endoplasmic reticulum stress J:317126
Lewy bodies J:317126
neuron degeneration J:317126
oxidative stress J:317126
Pla2g6tm1a(EUCOMM)Wtsi/Pla2g6tm1a(EUCOMM)Wtsi
C57BL/6N-Pla2g6tm1a(EUCOMM)Wtsi/Wtsi 		male infertility J:211773
Pla2g6tm1Tsu/Pla2g6tm1Tsu
involves: 129S2/SvPas * C57BL/6 		abnormal axon morphology J:174587
abnormal cell cytoskeleton morphology J:174587
abnormal gait J:132853
abnormal mitochondrial crista morphology J:174587
abnormal mitochondrial morphology J:174587
abnormal myelin sheath morphology J:174587
abnormal sciatic nerve morphology J:132853, J:174587
abnormal spinal cord grey matter morphology J:174587
abnormal spinal cord ventral horn morphology J:174587
abnormal synaptic bouton morphology J:174587
ataxia J:132853
axon degeneration J:174587
axonal dystrophy J:174587
axonal spheroids J:174587
impaired coordination J:132853
impaired limb coordination J:132853
kyphosis J:132853
neurodegeneration J:132853
premature death J:132853
reduced male fertility J:132853
weight loss J:132853
Pla2g6tm1Turk/Pla2g6tm1Turk
involves: 129X1/SvJ 		abnormal gait J:131429
abnormal locomotor coordination J:131429
abnormal motor coordination/balance J:131429
asthenozoospermia J:92835
impaired coordination J:131429
impaired limb coordination J:131429
increased exploration in new environment J:131429
neurodegeneration J:131429
reduced male fertility J:92835
Pla2g6tm1Zyao/Pla2g6tm1Zyao
involves: 129S6/SvEvTac * C57BL/6 		abnormal apolipoprotein level J:203038
blindness J:203038
increased cholesterol level J:203038
male infertility J:203038
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory