Irf3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf3
interferon regulatory factor 3
MGI:1859179

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irf3^tm1Ttg/Irf3^tm1Ttg B6.129-Irf3^tm1Ttg	abnormal retina outer nuclear layer morphology	J:281010
	abnormal retina outer plexiform layer morphology	J:281010
	decreased a-wave amplitude	J:281010
	decreased b-wave amplitude	J:281010
	decreased total retina thickness	J:281010
	retina degeneration	J:281010
	retina outer nuclear layer degeneration	J:281010
	thin retina outer nuclear layer	J:281010
	thin retina outer plexiform layer	J:281010
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6	decreased cellular sensitivity to ultraviolet irradiation	J:150948
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6J	abnormal circulating interferon level	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg involves: 129S/SvEv * C57BL/6J	increased susceptibility to Picornaviridae infection	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg Irf7^tm1Ttg/Irf7^tm1Ttg involves: 129P2/OlaHsd * 129S/SvEv	decreased interferon-beta secretion	J:158969
	decreased interleukin-1 beta secretion	J:158969
	increased susceptibility to bacterial infection	J:158969
	increased susceptibility to Herpesvirales infection	J:158969
	increased susceptibility to Paramyxoviridae infection	J:158969
Irf3^tm1Ttg/Irf3^tm1Ttg Irf9^tm1Ttg/Irf9^tm1Ttg involves: 129S/SvEv * C57BL/6J	abnormal cytokine secretion	J:98127
Irf3^tm1Ttg/Irf3^tm1Ttg Sting1^em1Jmin/Sting1^em1Jmin involves: 129S/SvEv * C57BL/6N	decreased single-positive T cell number	J:251372
	increased myeloid cell number	J:251372
	lung inflammation	J:251372

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24