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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf6
interferon regulatory factor 6
MGI:1859211
80 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irf6clft1/Irf6clft1
involves: A/J * FVB 		abnormal hindlimb morphology J:160190
abnormal mouth morphology J:160190
abnormal palatine bone horizontal plate morphology J:160190
abnormal skeleton morphology J:160190
cleft secondary palate J:160190
curly tail J:160190
delayed skin barrier formation J:160190
failure of palatal shelf elevation J:160190
fused phalanges J:160190
glossopalatal ankylosis J:160190
palatal shelf fusion with tongue or mandible J:160190
short forelimb J:160190
syndactyly J:160190
Irf6em1(IMPC)Wtsi/Irf6em1(IMPC)Wtsi
C57BL/6N-Irf6em1(IMPC)Wtsi/Wtsi 		increased circulating aspartate transaminase level J:211773
increased circulating creatine kinase level J:211773
increased circulating creatinine level J:211773
Irf6Gt(OST398253)Lex/Irf6+
involves: 129S5/SvEvBrd * C57BL/6 		abnormal craniofacial development J:226218
abnormal periderm development J:226218
Irf6Gt(OST398253)Lex/Irf6Gt(OST398253)Lex
involves: 129S5/SvEvBrd 		abnormal skin development J:180634
failure of palatal shelf elevation J:160190
palatal shelf fusion with tongue or mandible J:160190
Irf6Gt(OST398253)Lex/Irf6Gt(OST398253)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal cranium morphology J:115343
abnormal digit morphology J:115343
abnormal epidermal layer morphology J:115343
abnormal epidermis stratum spinosum morphology J:115343
abnormal esophagus morphology J:115343
abnormal jaw morphology J:115343
abnormal keratinocyte differentiation J:115343
abnormal mandibular angle morphology J:115343
abnormal oral cavity morphology J:226218
abnormal palate development J:226218
abnormal periderm development J:226218
abnormal phalanx morphology J:115343
absent epidermis stratum corneum J:115343
absent epidermis stratum granulosum J:115343
absent outer ear J:115343
absent presphenoid bone J:115343
cleft palate J:226218
cleft secondary palate J:115343
decreased length of long bones J:115343
delayed bone ossification J:115343
increased keratinocyte proliferation J:115343
perinatal lethality, complete penetrance J:94918
round snout J:115343
shiny skin J:115343
short forelimb J:115343
short snout J:115343
short sternum J:115343
short tail J:115343
small mandible J:115343
small vertebrae J:115343
split xiphoid process J:115343
synostosis J:115343
thick epidermis J:115343
tight skin J:115343
Irf6tm1.1Bcsl/Irf6tm1.1Bcsl
Not Specified 		abnormal skin development J:180634
Irf6tm1Bcsl/Irf6tm1Bcsl
Pitx2tm4(cre)Jfm/Pitx2+
involves: 129 		abnormal ameloblast morphology J:275989
abnormal enamel development J:275989
abnormal enamel mineralization J:275989
abnormal enamel morphology J:275989
abnormal enamel rod pattern J:275989
abnormal Hertwig epithelial root sheath morphology J:275989
abnormal incisor color J:275989
abnormal incisor morphology J:275989
abnormal molar crown morphology J:275989
abnormal molar cusp morphology J:275989
abnormal molar morphology J:275989
abnormal molar root morphology J:275989
abnormal tooth morphology J:275989
decreased molar number J:275989
reduced enamel thickness J:275989
supernumerary teeth J:275989
taurodontia J:275989
Irf6tm1Mjd/Irf6+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal mouth morphology J:116077
neonatal lethality, incomplete penetrance J:116077
Irf6tm1Mjd/Irf6tm1Mjd
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial development J:184926
abnormal incisor morphology J:184926
abnormal tooth development J:184926
failure of palatal shelf elevation J:160190
palatal shelf fusion with tongue or mandible J:160190
Irf6tm1Mjd/Irf6tm1Mjd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal craniofacial bone morphology J:116077
abnormal digit development J:116077
abnormal epidermal layer morphology J:116077
abnormal epidermis stratum basale morphology J:116077
abnormal epidermis suprabasal layer morphology J:116077
abnormal esophagus development J:116077
abnormal keratinocyte morphology J:116077
absent epidermis stratum corneum J:116077
absent epidermis stratum granulosum J:116077
absent vibrissae J:116077
cleft secondary palate J:116077
decreased hair follicle number J:116077
palatal shelf fusion with tongue or mandible J:116077
postnatal lethality, complete penetrance J:116077
shiny skin J:116077
short limbs J:116077
short tail J:116077
thick epidermis J:116077
Irf6tm1Mjd/Irf6tm1Pts
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal craniofacial phenotype J:184926
Irf6tm1Pts/Irf6tm1Pts
involves: 129 * C57BL/6 		normal craniofacial phenotype J:184926
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory