Irf7 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf7
interferon regulatory factor 7
MGI:1859212

10 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irf7^m1Btlr/Irf7⁺ C57BL/6J-Irf7^m1Btlr	decreased interferon-alpha secretion	J:159358
Irf7^m1Btlr/Irf7⁺ C57BL/6J-Irf7^m1Btlr	decreased interferon-beta secretion	J:159358
Irf7^m1Btlr/Irf7^m1Btlr C57BL/6J-Irf7^m1Btlr	decreased interferon-alpha secretion	J:159358
Irf7^m1Btlr/Irf7^m1Btlr C57BL/6J-Irf7^m1Btlr	decreased interferon-beta secretion	J:159358
Irf7^M2Btlr/Irf7⁺ C57BL/6J-Irf7^M2Btlr	decreased circulating interferon-beta level	J:217798
Irf7^M2Btlr/Irf7^M2Btlr C57BL/6J-Irf7^M2Btlr	decreased circulating interferon-beta level	J:217798
Irf7^{tm1(KOMP)Wtsi}/Irf7^{tm1(KOMP)Wtsi} C57BL/6N-Irf7^{tm1(KOMP)Wtsi}/Wtsi	abnormal retina morphology	J:211773
Irf7^tm1Ttg/Irf7^tm1Ttg B6.129P2-Irf7^tm1Ttg	increased susceptibility to Orthomyxoviridae infection	J:233979
Irf7^tm1Ttg/Irf7^tm1Ttg B6.129P2-Irf7^tm1Ttg	increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality	J:233979
Irf7^tm1Ttg/Irf7^tm1Ttg involves: 129P2/OlaHsd	abnormal interferon level	J:97662
	abnormal T cell physiology	J:97662
	increased susceptibility to Herpesvirales infection	J:97662
	increased susceptibility to Picornaviridae infection	J:97662

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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