Unc93b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Unc93b1
unc-93 homolog B1, TLR signaling regulator
MGI:1859307

54 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Unc93b1^3d/Unc93b1^3d C57BL/6-Unc93b1^3d	abnormal dendritic cell antigen presentation	J:159599
	abnormal dendritic cell morphology	J:159599
	decreased interleukin-6 secretion	J:159599
	decreased interleukin-12b secretion	J:159599
Unc93b1^3d/Unc93b1^3d C57BL/6J-Unc93b1^3d	abnormal antigen presentation via MHC class I	J:105484
	abnormal antigen presentation via MHC class II	J:105484
	abnormal circulating interferon level	J:105484
	abnormal dendritic cell antigen presentation	J:105484
	abnormal macrophage physiology	J:105484
	abnormal tumor necrosis factor secretion	J:105484
	decreased interleukin-12b secretion	J:105484
	increased circulating tumor necrosis factor level	J:105484
	increased susceptibility to bacterial infection	J:105484
	increased susceptibility to Herpesvirales infection	J:105484
Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	abnormal dendritic cell antigen presentation	J:211069
	abnormal dendritic cell morphology	J:211069
	abnormal dendritic cell physiology	J:211069
	abnormal tumor necrosis factor level	J:211069
	decreased circulating interleukin-6 level	J:211069
	decreased circulating interleukin-12b level	J:211069
Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy involves: 129P2/OlaHsd * C57BL/6	abnormal bone marrow morphology	J:174308
	abnormal cytokine secretion	J:174308
	abnormal erythrocyte physiology	J:174308
	abnormal liver morphology	J:174308
	abnormal T-helper 1 cell differentiation	J:174308
	abnormal T-helper 17 cell differentiation	J:174308
	anemia	J:174308
	decreased B cell proliferation	J:174308
	decreased interferon-alpha secretion	J:174308
	decreased interleukin-12b secretion	J:174308
	decreased marginal zone B cell number	J:174308
	decreased tumor necrosis factor secretion	J:174308
	enlarged spleen	J:174308
	glomerulonephritis	J:174308
	increased anti-nuclear antigen antibody level	J:174308
	increased autoantibody level	J:174308
	increased B cell number	J:174308
	increased B cell proliferation	J:174308
	increased CD4-positive, alpha-beta memory T cell number	J:174308
	increased circulating alanine transaminase level	J:174308
	increased circulating aspartate transaminase level	J:174308
	increased circulating bilirubin level	J:174308
	increased circulating creatinine level	J:174308
	increased circulating lactate dehydrogenase level	J:174308
	increased erythroblast number	J:174308
	increased IgG2a level	J:174308
	increased IgG2b level	J:174308
	increased interferon-alpha secretion	J:174308
	increased interleukin-12b secretion	J:174308
	increased memory T cell number	J:174308
	increased spleen weight	J:174308
	increased T-helper 1 cell number	J:174308
	increased T-helper 17 cell number	J:174308
	increased tumor necrosis factor secretion	J:174308
	liver failure	J:174308
	liver inflammation	J:174308
	multifocal hepatic necrosis	J:174308
	premature death	J:174308
	thrombocytopenia	J:174308

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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