Nfat5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfat5
nuclear factor of activated T cells 5
MGI:1859333

46 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nfat5^tm1.1Itl/Nfat5^tm1.1Itl Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * FVB/N	abnormal chloride level	J:201429
	abnormal lymphatic vessel morphology	J:201429
	increased mean systemic arterial blood pressure	J:201429
Nfat5^tm1.1Joar/Nfat5^tm1.1Joar Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2 * SJL	abnormal T cell physiology	J:148271
Nfat5^{tm1b(KOMP)Wtsi}/Nfat5⁺ C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J	decreased hematocrit	J:211773
	improved glucose tolerance	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating chloride level	J:211773
	increased circulating sodium level	J:211773
Nfat5^{tm1b(KOMP)Wtsi}/Nfat5^{tm1b(KOMP)Wtsi} C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J	preweaning lethality, incomplete penetrance	J:211773
Nfat5^tm1Rao/Nfat5^tm1Rao B6.129-Nfat5^tm1Rao	abnormal fluid regulation	J:88636
	abnormal kidney morphology	J:88636
	abnormal kidney outer medulla inner stripe morphology	J:88636
	abnormal kidney outer medulla morphology	J:88636
	abnormal kidney pelvis morphology	J:88636
	abnormal renal tubule epithelium morphology	J:88636
	abnormal renal tubule morphology	J:88636
	dilated renal tubule	J:88636
	increased kidney apoptosis	J:88636
	kidney atrophy	J:88636
	kidney papillary atrophy	J:88636
	lethality throughout fetal growth and development, incomplete penetrance	J:88636
	postnatal growth retardation	J:88636
	postnatal lethality, incomplete penetrance	J:88636
	tubulointerstitial nephritis	J:88636
Nfat5^tm1Skc/Nfat5^tm1Skc involves: 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system physiology	J:175527
	abnormal fetal cardiomyocyte proliferation	J:175527
	abnormal myocardial trabeculae morphology	J:175527
	abnormal myocardium compact layer morphology	J:175527
	anemia	J:175527
	edema	J:175527
	lethality throughout fetal growth and development, incomplete penetrance	J:175527
	prenatal lethality, complete penetrance	J:175527
	thin ventricular wall	J:175527
Nfat5^tm1Snh/Nfat5⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal immunoglobulin level	J:91482
	decreased IgG level	J:91482
	decreased T cell proliferation	J:91482
	spleen hypoplasia	J:91482
	thymus hypoplasia	J:91482
Nfat5^tm1Snh/Nfat5^tm1Snh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:91482
	perinatal lethality, complete penetrance	J:91482
Tg(CD2-Nfat5)1Snh/0 involves: BALB/c * C57BL/6	abnormal cytotoxic T cell physiology	J:80066
	abnormal T cell differentiation	J:80066
	abnormal T cell physiology	J:80066
	decreased CD4-positive, alpha-beta T cell number	J:80066
	decreased CD8-positive, alpha-beta T cell number	J:80066
	decreased splenocyte proliferation	J:80066
	decreased T cell number	J:80066
	decreased T cell proliferation	J:80066
	spleen hypoplasia	J:80066
	thymus hypoplasia	J:80066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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