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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dll4
delta like canonical Notch ligand 4
MGI:1859388
60 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dll4tm1Frad/Dll4+
Isl1tm1(cre)Tmj/Isl1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiac outflow tract development J:308916
abnormal pulmonary valve morphology J:308916
double outlet right ventricle J:308916
overriding aortic valve J:308916
ventricular septal defect J:308916
Dll4tm1Frad/Dll4tm1Frad
Foxn1tm3(cre)Nrm/Foxn1+
B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm 		abnormal T cell differentiation J:143472
abnormal thymus cell ratio J:143472
decreased CD4-positive, alpha-beta T cell number J:143472
decreased CD8-positive, alpha-beta T cell number J:143472
decreased double-positive T cell number J:143472
decreased thymocyte number J:143472
increased immature B cell number J:143472
Dll4tm1Frad/Dll4tm1Frad
Tg(Mx1-cre)1Cgn/0
B6.Cg-Dll4tm1Frad Tg(Mx1-cre)1Cgn 		normal immune system phenotype J:143472
Dll4tm1Grid/Dll4+
either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal anterior cardinal vein morphology J:93125
abnormal capillary morphology J:93125
abnormal common cardinal vein morphology J:93125
abnormal dorsal aorta morphology J:93125
abnormal vascular regression J:93125
abnormal vitelline vascular remodeling J:93125
arteriovenous malformation J:93125
blood vessel atresia J:93125
embryonic growth retardation J:93125
pericardial effusion J:93125
preweaning lethality, complete penetrance J:93125
Dll4tm1Jrt/Dll4+
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:93157
Dll4tm1Jrt/Dll4+
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal cardinal vein morphology J:93157
abnormal dorsal aorta morphology J:93157
abnormal pericardial cavity morphology J:93157
abnormal placenta vasculature J:93157
abnormal umbilical artery morphology J:93157
abnormal vitelline vasculature morphology J:93157
embryonic growth retardation J:93157
poor circulation J:93157
prenatal lethality, incomplete penetrance J:93157
Dll4tm1Jrt/Dll4tm1Jrt
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal anterior cardinal vein morphology J:93157
abnormal artery morphology J:93157
abnormal dorsal aorta morphology J:93157
abnormal heart atrium morphology J:93157
abnormal heart ventricle morphology J:93157
abnormal sinus venosus morphology J:93157
abnormal vascular branching morphogenesis J:93157
abnormal vascular development J:93157
abnormal vascular regression J:93157
abnormal vein morphology J:93157
abnormal vitelline vascular remodeling J:93157
embryonic growth retardation J:93157
embryonic lethality during organogenesis, complete penetrance J:93157
pericardial edema J:93157
trabecula carnea hypoplasia J:93157
Dll4tm1Kaho/Dll4tm1Kaho
Tg(Foxn1-cre)8Ghr/0
involves: C57BL/6 * DBA/2 		abnormal lymphopoiesis J:143473
absent CD4-positive, alpha-beta T cells J:143473
absent CD8-positive, alpha-beta T cells J:143473
decreased double-positive T cell number J:143473
thymus hypoplasia J:143473
Dll4tm1Nwg/Dll4+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		abnormal artery development J:94740
abnormal blood vessel morphology J:94740
abnormal cardinal vein morphology J:94740
abnormal dorsal aorta morphology J:94740
abnormal induced retina neovascularization J:177797
abnormal internal carotid artery morphology J:94740
abnormal placenta vasculature J:94740
abnormal vascular development J:94740
abnormal vascular regression J:94740
abnormal vascular smooth muscle morphology J:94740
abnormal vein development J:94740
abnormal visceral yolk sac morphology J:94740
absent vitelline blood vessels J:94740
aorta stenosis J:94740
embryo tissue necrosis J:94740
embryonic lethality during organogenesis, incomplete penetrance J:94740
Dll4tm1Nwg/Dll4+
involves: 129S6/SvEvTac * C57BL/6NTac * ICR 		embryonic lethality during organogenesis, incomplete penetrance J:94740
Dll4tm1Vlcg/Dll4tm1Vlcg
Not Specified 		no abnormal phenotype detected J:177290
Dll4tm2.1Vlcg/Dll4+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac 		abnormal induced retina neovascularization J:177797
abnormal vascular regression J:177797
Dll4tm2.1Vlcg/Dll4+
Tg(Nanog-cre)#Vlcg/0
involves: 129S6/SvEvTac * C57BL/6NTac 		abnormal angiogenesis J:200671
abnormal embryo development J:200671
Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6NTac 		abnormal retina vasculature morphology J:200671
Dll4tm3.1Vlcg/Dll4+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory