Mefv Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mefv
Mediterranean fever
MGI:1859396

9 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mefv^tm1Bhk/Mefv^tm1Bhk 129S6/SvEvTac-Mefv^tm1Bhk	normal immune system phenotype	J:192443
	increased interleukin-1 beta secretion	J:192443
	increased interleukin-18 secretion	J:192443
Mefv^tm1Chae/Mefv^tm1Chae either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	abnormal body temperature homeostasis	J:82763
	decreased macrophage apoptosis	J:82763
	increased inflammatory response	J:82763
	increased susceptibility to endotoxin shock	J:82763
Mefv^{tm2.1(MEFV)Chae}/Mefv⁺ chimera involves: 129S6/SvEvTac	abnormal male reproductive system physiology	J:172117
Mefv^tm6Chae/Mefv^tm6Chae B6.129S6-Mefv^tm6Chae	no abnormal phenotype detected	J:172117

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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