Pdgfc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdgfc
platelet-derived growth factor, C polypeptide
MGI:1859631

28 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdgfc^{Gt(OST91573)Lex}/Pdgfc^{Gt(OST91573)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal retina pigmentation	J:171883
Pdgfc^tm1.1Hdin/Pdgfc^tm1.1Hdin involves: 129 * C57BL/6 * FVB/N * SJL	abnormal nasal septum morphology	J:128709
	blistering	J:128709
	cleft secondary palate	J:128709
	palatal shelves fail to meet at midline	J:128709
Pdgfc^{tm1b(EUCOMM)Hmgu}/Pdgfc⁺ C57BL/6N-Pdgfc^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal kidney morphology	J:211773
	abnormal lean body mass	J:211773
	abnormal liver morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	decreased heart rate	J:211773
	enlarged spleen	J:211773
	increased CD4-negative, CD25-positive NK T cell number	J:211773
	increased circulating creatinine level	J:211773
	increased granulocyte number	J:211773
	increased monocyte cell number	J:211773
	increased red blood cell distribution width	J:211773
Pdgfc^{tm1b(EUCOMM)Hmgu}/Pdgfc^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pdgfc^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, incomplete penetrance	J:211773
Pdgfc^tm1Hdin/Pdgfc^tm1Hdin involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	no abnormal phenotype detected	J:128709
Pdgfc^tm1Nagy/Pdgfc^tm1Nagy involves: 129S1/Sv * 129X1/SvJ	abnormal palatal shelf fusion at midline	J:93954
	abnormal palate bone morphology	J:93954
	blistering	J:93954
	cleft secondary palate	J:93954
	edema	J:93954
	failure of palatal shelf elevation	J:93954
	neonatal lethality, incomplete penetrance	J:93954
	palatal shelf hypoplasia	J:93954
	postnatal lethality, complete penetrance	J:93954
	short nasal septum	J:93954
	spina bifida occulta	J:93954
Pdgfc^tm1Nagy/Pdgfc^tm1Nagy involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased small intestinal villus number	J:205009
	spina bifida occulta	J:205009

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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