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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nphs1
nephrosis 1, nephrin
MGI:1859637
29 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
involves: 129P2/OlaHsd * C57BL/6 		fused podocyte foot processes J:86048
Nphs1Gt(pT1Betageo)1Ruiz/Nphs1Gt(pT1Betageo)1Ruiz
involves: 129P2/OlaHsd * C57BL/6 		abnormal kidney morphology J:85162
abnormal podocyte foot process morphology J:86048
abnormal podocyte slit junction morphology J:86048
abnormal renal glomerulus morphology J:86048
absent podocyte slit diaphragm J:86048
dilated renal glomerular capsule J:86048
dilated renal tubule J:86048
expanded mesangial matrix J:86048
fused podocyte foot processes J:86048
increased urine protein level J:86048
neonatal lethality, incomplete penetrance J:86048
postnatal lethality, complete penetrance J:86048
renal glomerulus fibrosis J:86048
Nphs1tm1.1Tbh/Nphs1tm1.1Tbh
involves: C57BL/6 * CBA 		abnormal podocyte foot process morphology J:241326
abnormal podocyte slit diaphragm morphology J:241326
abnormal renal reabsorption J:241326
increased urine protein level J:241326
perinatal lethality, incomplete penetrance J:241326
postnatal lethality, complete penetrance J:241326
Nphs1tm1Afrn/Nphs1+
involves: C57BL/6 * DBA 		no abnormal phenotype detected J:101977
Nphs1tm1Ktry/Nphs1tm1Ktry
involves: 129X1/SvJ * C57BL/6 		abnormal podocyte foot process morphology J:66970
absent podocyte slit diaphragm J:66970
albuminuria J:66970
dilated distal convoluted tubule J:66970
dilated proximal convoluted tubule J:66970
edema J:66970
enlarged kidney J:66970
increased glomerular capsule space J:66970
increased kidney weight J:66970
increased mesangial cell number J:66970
increased urine protein level J:66970
kidney cortex cyst J:66970
kidney medulla cyst J:66970
neonatal lethality, incomplete penetrance J:66970
normal nervous system phenotype J:66970
podocyte foot process effacement J:66970
Nphs1tm1Rkl/Nphs1tm1Rkl
involves: 129S2/SvPasCrl 		absent podocyte slit diaphragm J:78616
dilated renal tubule J:78616
increased glomerular capsule space J:78616
increased urine protein level J:78616
postnatal lethality, complete penetrance J:78616
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory