Gabbr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
MGI:1860139

56 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gabbr1^{Gt(KST229)Byg}/Gabbr1^{Gt(KST229)Byg} involves: 129P2/OlaHsd * C57BL/6	neonatal lethality, complete penetrance	J:70273
Gabbr1^tm1Bet/Gabbr1⁺ BALB/c-Gabbr1^tm1Bet	abnormal emotion/affect behavior	J:103534
Gabbr1^tm1Bet/Gabbr1⁺ BALB/c-Gabbr1^tm1Bet	impaired passive avoidance behavior	J:70558
Gabbr1^tm1Bet/Gabbr1^tm1Bet BALB/c-Gabbr1^tm1Bet	abnormal axon morphology	J:132683
	abnormal estrous cycle	J:115850
	abnormal excitatory postsynaptic currents	J:70558
	abnormal gait	J:132683
	abnormal inhibitory postsynaptic currents	J:70558
	abnormal lumbar dorsal root ganglion morphology	J:132683
	abnormal myelin sheath morphology	J:132683
	abnormal myelination	J:132683
	abnormal nervous system electrophysiology	J:70558
	abnormal sciatic nerve morphology	J:132683
	abnormal somatic nervous system morphology	J:132683
	abnormal synaptic transmission	J:70558
	absence seizures	J:70558
	audiogenic seizures	J:70558
	clonic seizures	J:70558
	decreased depression-related behavior	J:103534
	decreased physiological sensitivity to xenobiotic	J:70558
	decreased thermal nociceptive threshold	J:70558, J:132683
	normal growth/size/body region phenotype	J:115850
	hyperresponsive to tactile stimuli	J:70558
	hyporesponsive to tactile stimuli	J:132683
	impaired behavioral response to xenobiotic	J:70558, J:101866
	impaired passive avoidance behavior	J:70558
	increased anxiety-related response	J:101866, J:103534
	increased circulating luteinizing hormone level	J:115850
	increased circulating prolactin level	J:115850
	increased locomotor activity	J:70558
	prolonged estrus	J:115850
	reduced female fertility	J:115850
	reduced long-term potentiation	J:113340
	seizures	J:70558
	short proestrus	J:115850
	tonic-clonic seizures	J:70558
Gabbr1^tm1Dgen/Gabbr1^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	abnormal posture	J:101679
	absent subcutaneous adipose tissue	J:101679
	decreased locomotor activity	J:101679
	dehydration	J:101679
	premature death	J:101679
	weakness	J:101679
Gabbr1^tm1Pngl/Gabbr1⁺ involves: 129P2/OlaHsd * C57BL/6J	increased prepulse inhibition	J:70254
Gabbr1^tm1Pngl/Gabbr1^tm1Pngl involves: 129P2/OlaHsd * C57BL/6J	abnormal action potential	J:70254
	abnormal inhibitory postsynaptic potential	J:70254
	abnormal nervous system electrophysiology	J:70254
	decreased body weight	J:70254
	normal nervous system phenotype	J:70254
	postnatal lethality, incomplete penetrance	J:70254
	sporadic seizures	J:70254
	tonic-clonic seizures	J:70254
Gabbr1^tm2.1Bet/Gabbr1^tm2.1Bet BALB/c-Gabbr1^tm2.1Bet	abnormal body temperature homeostasis	J:94234
Gabbr1^tm2.1Bet/Gabbr1^tm2.1Bet BALB/c-Gabbr1^tm2.1Bet	increased locomotor activity	J:94234
Gabbr1^tm2Bet/Gabbr1^tm2Bet BALB/c-Gabbr1^tm2Bet	normal behavior/neurological phenotype	J:94234
Gabbr1^tm2Bet/Gabbr1^tm2Bet Hdc^{tm1.1(icre)Wwis}/Hdc⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal habituation to a new environment	J:188103
	abnormal neuron physiology	J:188103
	normal behavior/neurological phenotype	J:188103
Gabbr1^tm2Bet/Gabbr1^tm2Bet Tg(HCRT-cre)1Stak/0 involves: BALB/cA * C57BL/6 * DBA/1	abnormal CNS synaptic transmission	J:146778
	abnormal inhibitory postsynaptic currents	J:146778
	abnormal sleep pattern	J:146778
	normal nervous system phenotype	J:146778
Gabbr1^tm3Bet/Gabbr1^tm3Bet BALB/c-Gabbr1^tm3Bet	abnormal conditioned taste aversion behavior	J:111889
	abnormal excitatory postsynaptic currents	J:113340, J:276486
	abnormal object recognition memory	J:113340
	reduced long-term potentiation	J:113340
Gabbr1^tm4Bet/Gabbr1^tm4Bet BALB/c-Gabbr1^tm4Bet	abnormal conditioned taste aversion behavior	J:111889
Gabbr1^tm4Bet/Gabbr1^tm4Bet BALB/c-Gabbr1^tm4Bet	abnormal inhibitory postsynaptic currents	J:113340

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24