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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
MGI:1860139
56 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gabbr1Gt(KST229)Byg/Gabbr1Gt(KST229)Byg
involves: 129P2/OlaHsd * C57BL/6 		neonatal lethality, complete penetrance J:70273
Gabbr1tm1Bet/Gabbr1+
BALB/c-Gabbr1tm1Bet 		abnormal emotion/affect behavior J:103534
impaired passive avoidance behavior J:70558
Gabbr1tm1Bet/Gabbr1tm1Bet
BALB/c-Gabbr1tm1Bet 		abnormal axon morphology J:132683
abnormal estrous cycle J:115850
abnormal excitatory postsynaptic currents J:70558
abnormal gait J:132683
abnormal inhibitory postsynaptic currents J:70558
abnormal lumbar dorsal root ganglion morphology J:132683
abnormal myelin sheath morphology J:132683
abnormal myelination J:132683
abnormal nervous system electrophysiology J:70558
abnormal sciatic nerve morphology J:132683
abnormal somatic nervous system morphology J:132683
abnormal synaptic transmission J:70558
absence seizures J:70558
audiogenic seizures J:70558
clonic seizures J:70558
decreased depression-related behavior J:103534
decreased physiological sensitivity to xenobiotic J:70558
decreased thermal nociceptive threshold J:70558, J:132683
normal growth/size/body region phenotype J:115850
hyperresponsive to tactile stimuli J:70558
hyporesponsive to tactile stimuli J:132683
impaired behavioral response to xenobiotic J:70558, J:101866
impaired passive avoidance behavior J:70558
increased anxiety-related response J:101866, J:103534
increased circulating luteinizing hormone level J:115850
increased circulating prolactin level J:115850
increased locomotor activity J:70558
prolonged estrus J:115850
reduced female fertility J:115850
reduced long-term potentiation J:113340
seizures J:70558
short proestrus J:115850
tonic-clonic seizures J:70558
Gabbr1tm1Dgen/Gabbr1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		abnormal posture J:101679
absent subcutaneous adipose tissue J:101679
decreased locomotor activity J:101679
dehydration J:101679
premature death J:101679
weakness J:101679
Gabbr1tm1Pngl/Gabbr1+
involves: 129P2/OlaHsd * C57BL/6J 		increased prepulse inhibition J:70254
Gabbr1tm1Pngl/Gabbr1tm1Pngl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal action potential J:70254
abnormal inhibitory postsynaptic potential J:70254
abnormal nervous system electrophysiology J:70254
decreased body weight J:70254
normal nervous system phenotype J:70254
postnatal lethality, incomplete penetrance J:70254
sporadic seizures J:70254
tonic-clonic seizures J:70254
Gabbr1tm2.1Bet/Gabbr1tm2.1Bet
BALB/c-Gabbr1tm2.1Bet 		abnormal body temperature homeostasis J:94234
increased locomotor activity J:94234
Gabbr1tm2Bet/Gabbr1tm2Bet
BALB/c-Gabbr1tm2Bet 		normal behavior/neurological phenotype J:94234
Gabbr1tm2Bet/Gabbr1tm2Bet
Hdctm1.1(icre)Wwis/Hdc+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal habituation to a new environment J:188103
abnormal neuron physiology J:188103
normal behavior/neurological phenotype J:188103
Gabbr1tm2Bet/Gabbr1tm2Bet
Tg(HCRT-cre)1Stak/0
involves: BALB/cA * C57BL/6 * DBA/1 		abnormal CNS synaptic transmission J:146778
abnormal inhibitory postsynaptic currents J:146778
abnormal sleep pattern J:146778
normal nervous system phenotype J:146778
Gabbr1tm3Bet/Gabbr1tm3Bet
BALB/c-Gabbr1tm3Bet 		abnormal conditioned taste aversion behavior J:111889
abnormal excitatory postsynaptic currents J:113340, J:276486
abnormal object recognition memory J:113340
reduced long-term potentiation J:113340
Gabbr1tm4Bet/Gabbr1tm4Bet
BALB/c-Gabbr1tm4Bet 		abnormal conditioned taste aversion behavior J:111889
abnormal inhibitory postsynaptic currents J:113340
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory