Mad2l1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mad2l1
MAD2 mitotic arrest deficient-like 1
MGI:1860374

26 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mad2l1^tm1Sorg/Mad2l1⁺ involves: 129S2/SvPas	abnormal cell physiology	J:117337
	abnormal chromosome number	J:117337
	aneuploidy	J:105717, J:117337
	increased incidence of induced tumors	J:117337
Mad2l1^tm1Sorg/Mad2l1⁺ involves: 129S2/SvPas * C57BL/6	normal cellular phenotype	J:62829
	chromosome breakage	J:67456
	increased lung adenocarcinoma incidence	J:67456
	increased spleen germinal center number	J:62829
Mad2l1^tm1Sorg/Mad2l1^tm1Sorg involves: 129S2/SvPas * C57BL/6	abnormal embryonic tissue morphology	J:62829
	abnormal inner cell mass apoptosis	J:62829
	abnormal mitosis	J:62829
	abnormal mitotic spindle assembly checkpoint	J:62829
	absent inner cell mass proliferation	J:62829
	decreased embryo size	J:62829
	normal embryo phenotype	J:62829
	embryonic lethality between implantation and somite formation, complete penetrance	J:62829
	increased embryonic tissue cell apoptosis	J:62829
	inner cell mass degeneration	J:62829
Mad2l1^tm2Sorg/Mad2l1^tm2Sorg Tg(KRT14-cre)1Amc/? Not Specified	abnormal epidermal layer morphology	J:194539
	abnormal hair follicle bulge morphology	J:194539
	abnormal hair follicle morphology	J:194539
	abnormal hair follicle physiology	J:194539
	abnormal skin physiology	J:194539
	aneuploidy	J:194539
	hairless	J:194539
	hyperkeratosis	J:194539
	postnatal lethality, incomplete penetrance	J:194539

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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