Gucy1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gucy1b1
guanylate cyclase 1, soluble, beta 1
MGI:1860604

29 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb involves: 129 * C57BL/6 * FVB/N	abnormal cecum morphology	J:121321
	abnormal intestinal transit time	J:121321
	abnormal intestine morphology	J:121321
	abnormal platelet activation	J:121321
	abnormal systemic arterial blood pressure	J:121321
	abnormal vasodilation	J:121321
	decreased body weight	J:121321
	dilated esophagus	J:121321
	dilated gallbladder	J:121321
	distended cecum	J:121321
	embryonic lethality between implantation and somite formation, complete penetrance	J:121321
	enlarged cecum	J:121321
	enlarged stomach	J:121321
	increased systemic arterial systolic blood pressure	J:121321
	intestinal hypoperistalsis	J:121321
	neonatal lethality, incomplete penetrance	J:121321
	peritoneal inflammation	J:121321
	postnatal growth retardation	J:121321
	premature death	J:121321
Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb involves: 129X1/SvJ	normal nervous system phenotype	J:153212
Gucy1b1^tm1.2Frb/Gucy1b1^tm1.2Frb X/Tg(Myh11-icre/ERT2)1Soff B6.Cg-Gucy1b1^tm1.2Frb Tg(Myh11-icre/ERT2)1Soff	abnormal systemic arterial blood pressure	J:186053
	decreased vasodilation	J:186053
	hypertension	J:186053
	increased systemic arterial systolic blood pressure	J:186053
Gucy1b1^tm1Zhen/Gucy1b1^tm1Zhen B6.129P2-Gucy1b1^tm1Zhen	no abnormal phenotype detected	J:177066
Gucy1b1^tm1Zhen/Gucy1b1^tm1Zhen Tg(Pf4-icre)Q3Rsko/0 involves: 129P2/OlaHsd * C57BL/6J	abnormal platelet physiology	J:177066
	normal cardiovascular system phenotype	J:177066
	decreased platelet aggregation	J:177066
	decreased susceptibility to induced thrombosis	J:177066
	normal hematopoietic system phenotype	J:177066
	increased bleeding time	J:177066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24