About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgf21
fibroblast growth factor 21
MGI:1861377
61 phenotypes from 7 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Fgf21tm1.1Djm/Fgf21tm1.1Djm
involves: 129S6/SvEvTac * C57BL/6 		abnormal gluconeogenesis J:150831
decreased circulating glucose level J:150831
decreased circulating ketone body level J:150831
decreased oxygen consumption J:150831
decreased physiological sensitivity to xenobiotic J:150831
hypoglycemia J:150831
Fgf21tm1.2Djm/Fgf21tm1.2Djm
involves: 129S6/SvEvTac * C57BL/6 * SJL 		no abnormal phenotype detected J:150831
Fgf21tm1Emf/Fgf21tm1Emf
B6.Cg-Fgf21tm1Emf 		abnormal adipose tissue morphology J:157309
abnormal blood homeostasis J:157309
abnormal body weight J:157309
abnormal brown fat cell morphology J:157309
abnormal food intake J:157309
abnormal glucose homeostasis J:157309
abnormal hypothalamus secretion J:157309
abnormal lipid homeostasis J:157309
abnormal lipid level J:157309
abnormal liver physiology J:157309
decreased body temperature J:181337
decreased fatty acids level J:157309
decreased locomotor activity J:157309, J:181337
decreased oxygen consumption J:157309
hepatic steatosis J:157309
impaired adaptive thermogenesis J:181337
impaired glucose tolerance J:157309
impaired lipolysis J:157309
increased body weight J:157309
increased brown adipose tissue amount J:157309
increased circulating cholesterol level J:157309
increased circulating glucose level J:157309
increased circulating insulin level J:157309
increased circulating leptin level J:157309
increased circulating triglyceride level J:157309
increased creatine kinase activity J:181337
increased gonadal fat pad weight J:157309
increased lean body mass J:157309
increased liver glycogen level J:157309
increased liver triglyceride level J:157309
increased liver weight J:157309
increased total body fat amount J:157309
increased white fat cell size J:157309
Fgf21tm1Fdl/Fgf21tm1Fdl
B6.Cg-Fgf21tm1Fdl 		decreased circulating growth hormone level J:184999
decreased circulating insulin-like growth factor I level J:184999
increased body length J:184999
increased circulating growth hormone level J:184999
increased long bone epiphyseal plate size J:184999
increased width of hypertrophic chondrocyte zone J:184999
long tibia J:184999
Fgf21tm1Lex/Fgf21tm1Lex
involves: 129S5/SvEvBrd * C57BL/6N 		abnormal brown adipose tissue physiology J:240649
abnormal brown adipose tissue thermogenesis J:240649
abnormal white adipose tissue physiology J:240649
decreased physiological sensitivity to xenobiotic J:240649
Fgf21tm1Nit/Fgf21tm1Nit
C57BL/6-Fgf21tm1Nit 		abnormal circulating free fatty acids level J:157334
abnormal white fat cell size J:157334
normal behavior/neurological phenotype J:157334
decreased circulating free fatty acids level J:157334
decreased white adipose tissue amount J:157334
decreased white fat cell size J:157334
enhanced lipolysis J:157334
normal homeostasis/metabolism phenotype J:157334
impaired lipolysis J:157334
increased body weight J:157334
increased circulating free fatty acids level J:157334
increased circulating ketone body level J:157334
increased liver weight J:157334
increased white adipose tissue amount J:157334
increased white fat cell size J:157334
Tg(Apoe-Fgf21)1Sakl/0
Not Specified 		abnormal gluconeogenesis J:150831
increased liver glycogen level J:150831
increased oxygen consumption J:150831
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory