Gsk3b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437

51 phenotypes from 9 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gsk3b^tm1.1Atak/Gsk3b⁺ involves: C57BL/6	abnormal bone healing	J:211406
	abnormal contextual conditioning behavior	J:144055
	abnormal learning/memory/conditioning	J:144055
	abnormal skeleton development	J:211406
	abnormal spatial reference memory	J:144055
	normal behavior/neurological phenotype	J:144055
	increased compact bone volume	J:211406
	increased trabecular bone volume	J:211406
Gsk3b^tm1.1Ypc/Gsk3b^tm1.1Ypc Osr2^tm2(cre)Jian/Osr2⁺ involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	normal craniofacial phenotype	J:166721
	normal mortality/aging	J:166721
Gsk3b^tm1.1Ypc/Gsk3b^tm1.1Ypc Tg(Pitx2-cre)1Ych/0 involves: 129S4/SvJaeSor * C57BL/6	cleft secondary palate	J:166721
	failure of palatal shelf elevation	J:166721
	palatal shelves fail to meet at midline	J:166721
Gsk3b^tm1.2Ypc/Gsk3b^tm1.2Ypc involves: 129S4/SvJaeSor * C57BL/6 * CBA	abnormal palate development	J:166721
	complete cleft palate	J:166721
	failure of palatal shelf elevation	J:166721
	neonatal lethality, complete penetrance	J:166721
	palatal shelves fail to meet at midline	J:166721
Gsk3b^tm1Dgen/Gsk3b⁺ involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Gsk3b^tm1Dgen/Gsk3b^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	preweaning lethality, complete penetrance	J:101679
Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd	decreased myocardial infarct size	J:186597
	decreased P wave amplitude	J:235770
	increased myocardial infarct size	J:186597
	prolonged PR interval	J:235770
Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal glycogen homeostasis	J:98263
	normal homeostasis/metabolism phenotype	J:98263
Gsk3b^tm1Grc/Gsk3b⁺ involves: 129S6/SvEvTac	decreased myocardial infarct size	J:186597
Gsk3b^tm1Grc/Gsk3b⁺ involves: 129S6/SvEvTac	increased myocardial infarct size	J:186597
Gsk3b^tm1Grc/Gsk3b^tm1Grc involves: 129S6/SvEvTac * CD-1	abnormal sternum ossification	J:119186
	cleft secondary palate	J:119186
	delayed bone ossification	J:119186
	neonatal lethality, complete penetrance	J:119186
	palatal shelves fail to meet at midline	J:119186
	split sternum	J:119186
	xiphoid process foramen	J:119186
Gsk3b^tm1Grc/Gsk3b^tm1Jrw involves: 129 * 129S6/SvEvTac * CD-1	abnormal sternum ossification	J:119186
	cleft secondary palate	J:119186
	delayed bone ossification	J:119186
	neonatal lethality, complete penetrance	J:119186
	palatal shelves fail to meet at midline	J:119186
	split sternum	J:119186
	xiphoid process foramen	J:119186
Gsk3b^tm1Jrw/Gsk3b⁺ involves: 129 * C57BL/6	abnormal osteoblast physiology	J:129364
	abnormal skeleton physiology	J:129364
	enhanced osteoblast differentiation	J:129364
	increased bone mass	J:129364
	increased bone ossification	J:129364
	increased bone resorption	J:129364
	increased compact bone mass	J:129364
	increased compact bone thickness	J:129364
	increased trabecular bone mass	J:129364
	increased trabecular bone volume	J:129364
Gsk3b^tm1Jrw/Gsk3b⁺ involves: 129 * C57BL/6J	abnormal glucose homeostasis	J:135659
	behavioral despair	J:97268
	decreased circulating glucose level	J:135659
	decreased circulating insulin level	J:135659
	decreased exploration in new environment	J:97268
	decreased prepulse inhibition	J:161844
Gsk3b^tm1Jrw/Gsk3b^tm1Jrw involves: 129 * C57BL/6J	abnormal hepatocyte morphology	J:63274
	abnormal liver morphology	J:63274
	lethality throughout fetal growth and development, complete penetrance	J:63274
Gsk3b^tm1Jrw/Gsk3b^tm1Jrw involves: 129 * CD-1	abnormal sternum ossification	J:119186
	cleft secondary palate	J:119186
	delayed bone ossification	J:119186
	neonatal lethality, complete penetrance	J:119186
	palatal shelves fail to meet at midline	J:119186
	split sternum	J:119186
	xiphoid process foramen	J:119186
Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Tg(Ggt1-cre)M3Egn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	abnormal proximal convoluted tubule morphology	J:167190
	abnormal renal tubule morphology	J:167190
	increased glycogen level	J:167190
	normal renal/urinary system phenotype	J:167190
Gsk3b^tm2138.1Arte/Gsk3b^tm2138.1Arte C57BL/6-Gsk3b^tm2138.1Arte	abnormal Wallerian degeneration	J:188272

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