Gsk3b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437

37 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw involves: 129 * C57BL/6 * CBA	abnormal urinary bladder urothelium morphology	J:164579
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b⁺ involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	abnormal heart electrocardiography waveform feature	J:235770
	prolonged PR interval	J:235770
	prolonged QRS complex duration	J:235770
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	abnormal heart electrocardiography waveform feature	J:235770
	prolonged PR interval	J:235770
	prolonged QRS complex duration	J:235770
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b⁺ involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	abnormal S wave	J:235770
	cardiac fibrosis	J:235770
	decreased cardiac muscle contractility	J:235770
	prolonged PR interval	J:235770
	prolonged QRS complex duration	J:235770
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	abnormal S wave	J:235770
	cardiac fibrosis	J:235770
	decreased cardiac muscle contractility	J:235770
	increased Q wave amplitude	J:235770
	prolonged PR interval	J:235770
	prolonged QRS complex duration	J:235770
Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a⁺ Gsk3b^tm1Grc/Gsk3b⁺ involves: 129S6/SvEvTac * C57BL/6N	cleft palate	J:195008
Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a⁺ Gsk3b^tm1Grc/Gsk3b^tm1Grc involves: 129S6/SvEvTac * C57BL/6N	cleft palate	J:195008
Gsk3a^tm1Dral/Gsk3a^tm1Dral Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd	abnormal behavioral response to xenobiotic	J:200517
	abnormal long-term depression	J:200517
	decreased coping response	J:200517
	enhanced contextual conditioning behavior	J:200517
	hyperactivity	J:200517
	impaired cued conditioning behavior	J:200517
	increased anxiety-related response	J:200517
	increased circulating corticosterone level	J:200517
	increased circulating interleukin-6 level	J:200517
	increased exploration in new environment	J:200517
	increased thigmotaxis	J:200517
Gsk3a^tm1Dral/Gsk3a^tm1Dral Gsk3b^tm1Dral/Gsk3b^tm1Dral involves: 129P2/OlaHsd * C57BL/6 * CBA	normal homeostasis/metabolism phenotype	J:98263
	increased liver glycogen level	J:98263
Gsk3a^tm1Dral/Gsk3a^tm1Dral Gsk3b^tm1Dral/Gsk3b^tm1Dral Gys1^tm1.1Arte/Gys1^tm1.1Arte involves: 129P2/OlaHsd * C57BL/6J	abnormal glycogen homeostasis	J:167911
Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺ involves: 129 * C57BL/6J	abnormal circulating glucose level	J:135659
	abnormal circulating insulin level	J:135659
	decreased pancreatic beta cell mass	J:135659
	improved glucose tolerance	J:135659
	insulin resistance	J:135659
Gsk3b^tm1Jrw/Gsk3b⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal circulating glucose level	J:135659
	abnormal pancreatic islet cell apoptosis	J:135659
	normal growth/size/body region phenotype	J:135659
	increased circulating glucose level	J:135659
	increased circulating insulin level	J:135659
	increased pancreatic beta cell proliferation	J:135659
	insulin resistance	J:135659
Gsk3b^tm1Jrw/Gsk3b⁺ Runx2^tm1Kish/Runx2⁺ involves: 129 * 129P2/OlaHsd * C57BL/6	abnormal clavicle morphology	J:129364
	abnormal fontanelle morphology	J:129364
Gsk3b^tm1Jrw/Gsk3b⁺ Tph2^tm1Mca/Tph2^tm1Mca involves: 129 * 129S6/SvEvTac * C57BL/6J	abnormal social investigation	J:131619
	normal behavior/neurological phenotype	J:131619
Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal circulating glucose level	J:135659
	increased circulating insulin level	J:135659

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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