Rab27a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rab27a
RAB27A, member RAS oncogene family
MGI:1861441

43 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rab27a^ash-N/Rab27a^ash-N B10.F	abnormal coat/hair pigmentation	J:7366
	normal cellular phenotype	J:7366
	diluted coat color	J:7366
Rab27a^ash/Rab27a^ash B6.C3Sn-Rab27a^ash	abnormal cytotoxic T cell physiology	J:193137
	decreased body temperature	J:193137
	decreased cytotoxic T cell cytolysis	J:193137
	decreased erythrocyte cell number	J:193137
	decreased leukocyte cell number	J:193137
	decreased neutrophil cell number	J:193137
	decreased NK cell degranulation	J:193137
	hunched posture	J:193137
	increased circulating aspartate transaminase level	J:193137
	increased circulating interferon-gamma level	J:193137
	increased circulating interleukin-1 beta level	J:193137
	increased circulating interleukin-6 level	J:193137
	increased circulating lactate dehydrogenase level	J:193137
	increased circulating tumor necrosis factor level	J:193137
	increased susceptibility to Riboviria infection	J:193137
	lethargy	J:193137
	pancytopenia	J:193137
	thrombocytopenia	J:193137
	weight loss	J:193137
Rab27a^ash/Rab27a^ash C3H/HeSn-Rab27a^ash/J	abnormal platelet dense granule morphology	J:77395
	abnormal platelet dense granule physiology	J:77395
	decreased platelet ADP level	J:77395
	decreased platelet aggregation	J:77395
	decreased platelet ATP level	J:77395
	decreased platelet dense granule number	J:77395
	decreased platelet serotonin level	J:77395
	increased bleeding time	J:77395
Rab27a^ash/Rab27a^ash C3H/HeSn-Rab27a^ash/JRos	decreased platelet serotonin level	J:137593
Rab27a^ash/Rab27a^ash involves: C3H/HeDiSn	abnormal coat/hair pigmentation	J:4458
	abnormal Harderian gland pigmentation	J:4458
	abnormal melanocyte morphology	J:4458
	abnormal melanosome transport	J:134370
	abnormal NK cell degranulation	J:111253
	abnormal skin pigmentation	J:4458
	abnormal vesicle-mediated transport	J:134370
	decreased cytotoxic T cell cytolysis	J:67600, J:111253
	decreased platelet dense granule number	J:63231
	decreased platelet serotonin level	J:63231
	diluted coat color	J:4458
	normal immune system phenotype	J:111253
	impaired natural killer cell mediated cytotoxicity	J:111253
	increased bleeding time	J:63231
	normal integument phenotype	J:63231
	normal vision/eye phenotype	J:63231
Rab27a^cct/Rab27a^cct C57BL/6-Rab27a^cct	abnormal neutrophil physiology	J:114299
	hypopigmentation	J:114299
	normal immune system phenotype	J:114299
Rab27a^em1(IMPC)Bay/Rab27a^em1(IMPC)Bay C57BL/6N-Rab27a^em1(IMPC)Bay/BayMmucd	abnormal coat/hair pigmentation	J:211773
	limb grasping	J:211773
Rab27a^m1Anu/Rab27a^m1Anu C57BL/6JAnu-Rab27a^m1Anu	abnormal coat/hair pigmentation	J:104190
Rab27a^m2Btlr/Rab27a^m2Btlr C57BL/6J-Rab27a^m2Btlr	diluted coat color	J:221491
Rab27a^m3Btlr/Rab27a^m3Btlr C57BL/6J-Rab27a^m3Btlr	diluted coat color	J:231802

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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