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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Actl6a
actin-like 6A
MGI:1861453
28 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Actl6aem1(IMPC)J/Actl6a+
C57BL/6NJ-Actl6aem1(IMPC)J/Mmjax 		decreased circulating bilirubin level J:211773
decreased circulating phosphate level J:211773
decreased exploration in new environment J:211773
decreased mean corpuscular hemoglobin J:211773
Actl6aem1(IMPC)J/Actl6aem1(IMPC)J
C57BL/6NJ-Actl6aem1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Actl6atm1.1Grc/Actl6a+
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6J * CBA 		decreased common myeloid progenitor cell number J:192124
decreased granulocyte number J:192124
decreased macrophage cell number J:192124
Actl6atm1.1Grc/Actl6atm1.1Grc
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6J * CBA 		abnormal bone marrow cell physiology J:192124
abnormal definitive hematopoiesis J:192124
abnormal hematopoietic stem cell physiology J:192124
anemia J:192124
decreased B cell number J:192124
decreased bone marrow cell number J:192124
decreased common myeloid progenitor cell number J:192124
decreased erythrocyte cell number J:192124
decreased erythroid progenitor cell number J:192124
decreased granulocyte number J:192124
decreased hematopoietic stem cell number J:192124
decreased hematopoietic stem cell proliferation J:192124
decreased hemoglobin content J:192124
decreased leukocyte cell number J:192124
decreased lymphocyte cell number J:192124
decreased macrophage cell number J:192124
decreased megakaryocyte cell number J:192124
decreased monocyte cell number J:192124
increased erythroblast number J:192124
polycythemia J:192124
premature death J:192124
thrombocytopenia J:192124
Actl6atm1.2Grc/Actl6atm1.2Grc
involves: 129S6/SvEvTac 		embryonic lethality, complete penetrance J:192124
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory