Lgi1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgi1
leucine-rich repeat LGI family, member 1
MGI:1861691

37 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgi1^tm1.1Ics/Lgi1⁺ involves: 129S2/SvPas * BALB/c * C57BL/6	audiogenic seizures	J:182795
Lgi1^tm1.1Ics/Lgi1^tm1.1Ics involves: 129S2/SvPas * BALB/c * C57BL/6	abnormal brain wave pattern	J:182795
	abnormal cerebellar granule cell morphology	J:182795
	abnormal cerebellum external granule cell layer morphology	J:182795
	abnormal hippocampal mossy fiber morphology	J:182795
	abnormal spike wave discharge	J:182795
	akinesia	J:182795
	aphagia	J:182795
	decreased body size	J:182795
	decreased body weight	J:182795
	decreased total body fat amount	J:182795
	environmentally induced seizures	J:182795
	gliosis	J:182795
	neurodegeneration	J:182795
	postnatal growth retardation	J:182795
	postnatal lethality, complete penetrance	J:182795
	seizures	J:182795
	tonic-clonic seizures	J:182795
Lgi1^tm1Mafu/Lgi1⁺ involves: 129S6/SvEvTac * C57BL/6	clonic seizures	J:157578
	increased susceptibility to pharmacologically induced seizures	J:157578
	tonic seizures	J:157578
Lgi1^tm1Mafu/Lgi1^tm1Mafu involves: 129S6/SvEvTac * C57BL/6	abnormal glutamate-mediated receptor currents	J:157578
	decreased miniature excitatory postsynaptic current amplitude	J:157578
	normal nervous system phenotype	J:157578
	postnatal growth retardation	J:157578
	premature death	J:157578
	seizures	J:157578
	tonic-clonic seizures	J:157578
Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Pvalb^tm1(cre)Arbr/0 involves: 129/Sv * 129P2/OlaHsd * C57BL/6	normal nervous system phenotype	J:269784
Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Tg(Camk2a-cre)T29-1Stl/0 involves: 129/Sv * BALB/cJ * C57BL/6	normal nervous system phenotype	J:269784
Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Tg(CMV-cre)1Cgn/0 involves: 129/Sv * BALB/cJ * C57BL/6	abnormal cerebral cortex morphology	J:269784
	abnormal neocortex morphology	J:269784
	seizures	J:269784
Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Tg(GFAP-cre)25Mes/0 involves: 129/Sv * C57BL/6 * FVB/N	normal nervous system phenotype	J:269784
Lgi1^tm2.1Jkc/Lgi1^tm2.1Jkc Tg(Nes-cre)1Kln/0 involves: 129/Sv * C57BL/6 * SJL	abnormal cerebral cortex morphology	J:269784
	abnormal neocortex morphology	J:269784
	seizures	J:269784
Tg(Lgi1)#Mpan/0 Not Specified	abnormal axon pruning	J:154129
	abnormal dendrite morphology	J:154129
	abnormal miniature excitatory postsynaptic currents	J:154129
	abnormal paired-pulse facilitation	J:154129
	abnormal synaptic transmission	J:154129
	decreased excitatory postsynaptic current amplitude	J:154129
Tg(Lgi1*)#Mpan/0 Not Specified	abnormal axon pruning	J:154129
	abnormal CNS synaptic transmission	J:154129
	abnormal dendrite morphology	J:154129
	abnormal miniature excitatory postsynaptic currents	J:154129
	abnormal paired-pulse inhibition	J:154129
	abnormal synapse morphology	J:154129
	abnormal synaptic transmission	J:154129
	increased excitatory postsynaptic current amplitude	J:154129
	increased susceptibility to pharmacologically induced seizures	J:154129

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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