Slc12a5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc12a5
solute carrier family 12, member 5
MGI:1862037

65 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc12a5^em1(IMPC)Mbp/Slc12a5⁺ C57BL/6N-Slc12a5^em1(IMPC)Mbp/MbpMmucd	abnormal colon morphology	J:211773
	abnormal duodenum morphology	J:211773
	abnormal jejunum morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal stomach morphology	J:211773
	decreased bone mineral content	J:211773
	embryonic growth retardation	J:211773
	enlarged spleen	J:211773
	impaired glucose tolerance	J:211773
	small kidney	J:211773
	small spleen	J:211773
Slc12a5^em1(IMPC)Mbp/Slc12a5^em1(IMPC)Mbp C57BL/6N-Slc12a5^em1(IMPC)Mbp/MbpMmucd	abnormal blood vessel morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	edema	J:211773
	hemorrhage	J:211773
	microphthalmia	J:211773
	preweaning lethality, complete penetrance	J:211773
Slc12a5^tm1Dlp/Slc12a5⁺ involves: C57BL/6J	abnormal summary potential	J:113307
Slc12a5^tm1Dlp/Slc12a5⁺ involves: C57BL/6J	increased susceptibility to pharmacologically induced seizures	J:113307
Slc12a5^tm1Dlp/Slc12a5^tm1Dlp involves: 129 * C57BL/6J	abnormal brain interneuron morphology	J:113307
	abnormal gait	J:113307
	abnormal posture	J:113307
	abnormal summary potential	J:113307
	decreased body size	J:113307
	postnatal growth retardation	J:113307
	postnatal lethality, complete penetrance	J:113307
	tonic-clonic seizures	J:113307
Slc12a5^tm1Hsav/Slc12a5^tm1Hsav involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal nervous system electrophysiology	J:127091
Slc12a5^tm1Hsav/Slc12a5^tm2Hsav involves: 129S1/Sv * 129S2/SvPasHsd * 129X1/SvJ * C57BL/6J * C57BL/6JOlaHsd	abnormal habituation	J:101079
	decreased body weight	J:101079
	decreased vertical activity	J:101079
	hyporesponsive to tactile stimuli	J:101079
	impaired spatial learning	J:101079
	increased anxiety-related response	J:101079
	increased susceptibility to pharmacologically induced seizures	J:101079
	increased thermal nociceptive threshold	J:101079
	normal nervous system phenotype	J:101079
	normal reproductive system phenotype	J:101079
Slc12a5^tm1Hsav/Slc12a5^tm2Hsav involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:136887
Slc12a5^tm1Tjj/Slc12a5^tm1Tjj either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)	abnormal abdominal wall morphology	J:69625
	abnormal action potential	J:69625
	abnormal central pattern generator function	J:69625
	abnormal motor capabilities/coordination/movement	J:69625
	abnormal nervous system electrophysiology	J:69625
	abnormal somatic nervous system physiology	J:69625
	abnormal touch/ nociception	J:69625
	akinesia	J:69625
	atelectasis	J:69625
	neonatal lethality, complete penetrance	J:69625
	omphalocele	J:69625
	respiratory failure	J:69625
	trunk curl	J:69625
Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Gabra6^tm2(cre)Wwis/Gabra6⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal action potential	J:181930
	abnormal cerebellar granule cell morphology	J:181930
	abnormal learning/memory/conditioning	J:181930
	abnormal neuron morphology	J:181930
	normal behavior/neurological phenotype	J:181930
	normal nervous system phenotype	J:181930
Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Gabra6^tm2(cre)Wwis/Gabra6⁺ Tg(Pcp2-cre)2Mpin/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal GABA-mediated receptor currents	J:181930
	abnormal learning/memory/conditioning	J:181930
	abnormal motor learning	J:181930
	abnormal optokinetic reflex	J:181930
	abnormal vestibuloocular dark reflex	J:181930
	abnormal vestibuloocular light reflex	J:181930
	normal nervous system phenotype	J:181930
Slc12a5^tm2.1Tjj/Slc12a5^tm2.1Tjj Tg(Pcp2-cre)2Mpin/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal GABA-mediated receptor currents	J:181930
	abnormal learning/memory/conditioning	J:181930
	abnormal motor learning	J:181930
	abnormal neuron morphology	J:181930
	abnormal optokinetic reflex	J:181930
	abnormal Purkinje cell morphology	J:181930
	impaired ability to fire action potentials	J:181930
	normal nervous system phenotype	J:181930
	normal vision/eye phenotype	J:181930
Slc12a5^tm2Hsav/Slc12a5^tm2Hsav involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:136887
	abnormal miniature excitatory postsynaptic currents	J:136887
	abnormal synapse morphology	J:136887

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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