About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lmx1a
LIM homeobox transcription factor 1 alpha
MGI:1888519
20 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Rjo
involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 		abnormal fourth ventricle morphology J:152673
Lmx1adr-J/Lmx1adr-J
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Lmx1a-cre)1Kjmi/0
involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 		abnormal cerebellum development J:152673
abnormal cerebellum morphology J:152673
abnormal fourth ventricle morphology J:152673
small cerebellum J:152673
Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+
involves: 129S7/SvEvBrd * C57BL/6J 		decreased dopaminergic neuron number J:175535
Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+
involves: 129S7/SvEvBrd * C57BL/6J 		decreased dopaminergic neuron number J:175535
Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1btm1Rjo
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality J:175535
Lmx1atm1Tpe/Lmx1atm1Tpe
Lmx1btm1Zfc/Lmx1btm1Zfc
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal autophagy J:222854
abnormal innervation J:222854
abnormal lysosome morphology J:222854
abnormal lysosome physiology J:222854
abnormal synapse morphology J:222854
abnormal synaptic bouton morphology J:222854
abnormal synaptic vesicle number J:222854
decreased dopamine level J:222854
enhanced long-term potentiation J:222854
impaired coordination J:222854
impaired olfaction J:222854
impaired short-term object recognition memory J:222854
increased locomotor activity J:222854
neurodegeneration J:222854
Lmx1atm1Tpe/Lmx1atm1Tpe
Lmx1btm1Zfc/Lmx1btm1Zfc
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal synaptic bouton morphology J:222854
decreased dopamine level J:222854
neurodegeneration J:222854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory