Brd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Brd4
bromodomain containing 4
MGI:1888520

31 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Brd4^{Gt(pGT1.8TM)ST132Nimr}/Brd4⁺ involves: 129P2/Ola * C57BL/6J	abnormal craniofacial bone morphology	J:76662
	abnormal epididymis epithelium morphology	J:76662
	abnormal hepatocyte morphology	J:76662
	abnormal seminiferous tubule morphology	J:76662
	abnormal spermatogenesis	J:76662
	abnormal vas deferens morphology	J:76662
	cataract	J:76662
	embryonic growth retardation	J:76662
	microphthalmia	J:76662
	mixed cellular infiltration to dermis	J:76662
	postnatal growth retardation	J:76662
	postnatal lethality, incomplete penetrance	J:76662
	short mandible	J:76662
	short nasal bone	J:76662
	short premaxilla	J:76662
	thick epidermis	J:76662
Brd4^{Gt(pGT1.8TM)ST132Nimr}/Brd4^{Gt(pGT1.8TM)ST132Nimr} involves: 129P2/Ola * C57BL/6J	embryonic lethality, complete penetrance	J:76662
	inner cell mass degeneration	J:76662
Brd4^M1Rvt/Brd4⁺ involves: BALB/cAnNCrl * C3H/HeH	normal homeostasis/metabolism phenotype	J:277882
Brd4^M1Rvt/Brd4⁺ involves: BALB/cAnNCrl * C3H/HeH	nephrocalcinosis	J:277882
Brd4^{tm1b(EUCOMM)Wtsi}/Brd4⁺ C57BL/6N-Brd4^{tm1b(EUCOMM)Wtsi}/Bay	abnormal cranium morphology	J:211773
	abnormal eye posterior chamber depth	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina inner nuclear layer morphology	J:211773
	abnormal retina outer nuclear layer morphology	J:211773
	decreased prepulse inhibition	J:211773
	decreased total retina thickness	J:211773
	increased grip strength	J:211773
	short tibia	J:211773
Brd4^{tm1b(EUCOMM)Wtsi}/Brd4^{tm1b(EUCOMM)Wtsi} C57BL/6N-Brd4^{tm1b(EUCOMM)Wtsi}/Bay	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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