Apba3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apba3
amyloid beta precursor protein binding family A member 3
MGI:1888527

8 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Apba3^tm1.1Ski/Apba3^tm1.1Ski Lyz2^tm1(cre)Ifo/Lyz2⁺ B6.129-Apba3^tm1.1Ski Lyz2^tm1(cre)Ifo	decreased susceptibility to endotoxin shock	J:176742
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:176742
Apba3^tm1.1Sud/Apba3^tm1.1Sud involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:115573
Apba3^tm1.2Ski/Apba3^tm1.2Ski B6.129-Apba3^tm1.2Ski	abnormal macrophage physiology	J:176742
	decreased circulating interleukin-12 level	J:176742
	decreased circulating tumor necrosis factor level	J:176742
	decreased interleukin-12 secretion	J:176742
	decreased susceptibility to endotoxin shock	J:176742
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:176742
	decreased tumor necrosis factor secretion	J:176742

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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