Tbx21 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbx21
T-box 21
MGI:1888984

40 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tbx21^duane/Tbx21^duane C57BL/6-Tbx21^duane	abnormal NK cell differentiation	J:154069
	absent NK T cells	J:154069
	decreased NK cell number	J:154069
	increased NK cell number	J:154069
Tbx21^m1Btlr/Tbx21^m1Btlr C57BL/6J-Tbx21^m1Btlr	increased CD8-positive, alpha-beta T cell number	J:267478
	increased effector memory CD8-positive, alpha-beta T cell number	J:267478
	increased IgM level	J:267478
Tbx21^tm1Glm/Tbx21⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal cytokine level	J:73833
	abnormal interleukin level	J:73832
	abnormal NK cell physiology	J:73833
	abnormal respiratory system morphology	J:73832
	abnormal tumor necrosis factor level	J:73832
	decreased T helper 1 cell number	J:73833
	increased airway responsiveness	J:73832
Tbx21^tm1Glm/Tbx21^tm1Glm B6.129S6-Tbx21^tm1Glm	abnormal CD4-positive T cell differentiation	J:143729
Tbx21^tm1Glm/Tbx21^tm1Glm C.129S6-Tbx21^tm1Glm/J	abnormal CD4-positive, alpha-beta T cell physiology	J:111932
	abnormal cytokine secretion	J:111932
	CNS inflammation	J:111932
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:111932
Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S6/SvEvTac	abnormal cytokine level	J:112600
	abnormal leukocyte migration	J:163822
	decreased CD4-positive, alpha-beta T cell number	J:163822
	decreased memory T cell number	J:163822
	increased interleukin-17 secretion	J:163822
	increased susceptibility to induced colitis	J:141481
Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S6/SvEvTac * C57BL/6	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:73833
	abnormal cytokine level	J:73832
	abnormal immunoglobulin level	J:73833
	abnormal interleukin level	J:73832
	abnormal NK cell physiology	J:73833
	abnormal respiratory system morphology	J:73832
	abnormal T-helper 1 cell differentiation	J:73833
	abnormal tumor necrosis factor level	J:73832
	decreased interferon-gamma secretion	J:73833
	decreased T helper 1 cell number	J:73833
	impaired natural killer cell mediated cytotoxicity	J:73833
	increased airway responsiveness	J:73832
	increased natural killer cell mediated cytotoxicity	J:73833
	increased susceptibility to parasitic infection	J:73833
	increased T-helper 2 cell number	J:73833
	respiratory system inflammation	J:73832
Tbx21^tm1Srnr/Tbx21⁺ involves: C57BL/6	absent NK T cells	J:112679
Tbx21^tm1Srnr/Tbx21⁺ involves: C57BL/6	decreased NK cell number	J:112679
Tbx21^tm1Srnr/Tbx21^tm1Srnr involves: C57BL/6	abnormal T-helper 1 cell morphology	J:112679
Tbx21^tm1Srnr/Tbx21^tm1Srnr involves: C57BL/6	decreased NK T cell number	J:112679
Tbx21^tm2Srnr/Tbx21⁺ Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:174315
	increased susceptibility to Riboviria infection	J:174315
Tbx21^tm2Srnr/Tbx21^tm2Srnr Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:174315
	normal immune system phenotype	J:137655
	increased interleukin-2 secretion	J:174315
	increased interleukin-17 secretion	J:174315
	increased susceptibility to Riboviria infection	J:174315
	increased tumor necrosis factor secretion	J:174315

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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