Tbx21 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbx21
T-box 21
MGI:1888984

35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Eomes^tm1.1Bflu/Eomes^tm1.1Bflu Tbx21^tm1Glm/Tbx21^tm1Glm Tg(Cd4-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL	abnormal leukocyte migration	J:163822
	decreased CD4-positive, alpha-beta T cell number	J:163822
	decreased CD8-positive, alpha-beta T cell number	J:163822
	decreased interferon-gamma secretion	J:163822
	decreased memory T cell number	J:163822
	increased interleukin-4 secretion	J:163822
	increased interleukin-17 secretion	J:163822
	increased tumor incidence	J:163822
Eomes^tm1.1Twa/? Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S6/SvEvTac * C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1.1Twa/? Tg(CD2-Tbx21)#Staka/? involves: C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1Apr/Eomes⁺ Tbx21^tm1Srnr/Tbx21^tm1Srnr involves: C57BL/6	decreased interferon-gamma secretion	J:112679
	decreased memory T cell number	J:112679
	decreased NK cell number	J:112679
	decreased NK T cell number	J:112679
Eomes^tm1Srnr/Eomes^tm1Srnr Tbx21^tm1Srnr/Tbx21^tm1Srnr Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD8-positive, alpha-beta T cell differentiation	J:137655
	abnormal immune system physiology	J:137655
	abnormal interleukin level	J:137655
	abnormal leukocyte physiology	J:137655
	abnormal T cell morphology	J:137655
	decreased CD8-positive, alpha-beta T cell number	J:137655
	decreased memory T cell number	J:137655
	increased neutrophil cell number	J:137655
	increased susceptibility to Riboviria infection	J:137655
Ldlr^tm1Her/Ldlr^tm1Her Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	abnormal interleukin secretion	J:96110
	abnormal susceptibility to atherosclerosis	J:96110
	decreased IgG level	J:96110
	decreased interferon-gamma secretion	J:96110
	increased circulating cholesterol level	J:96110
	increased IgM level	J:96110
Rag2^tm1Fwa/Rag2^tm1Fwa Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S/SvEv * 129S6/SvEvTac	abnormal digestive system physiology	J:141481
	abnormal intestinal epithelium morphology	J:141481
	abnormal large intestine crypts of Lieberkuhn morphology	J:141481
	colitis	J:141481
	normal digestive/alimentary phenotype	J:141481
	increased tumor necrosis factor secretion	J:141481
	large intestinal inflammation	J:141481
	rectal prolapse	J:141481
Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} involves: 129S2/SvPas * C57BL/6	decreased interferon-gamma secretion	J:207104
Tbx21^tm1Glm/Tbx21^tm1Glm Tg(TRAMP)8247Ng/0 involves: 129S6/SvEvTac * C57BL/6	increased metastatic potential	J:88093
	increased prostate gland adenocarcinoma incidence	J:88093
	increased prostate gland tumor incidence	J:88093
	increased prostate intraepithelial neoplasia incidence	J:88093

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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