Adar Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adar
adenosine deaminase, RNA-specific
MGI:1889575

54 phenotypes from 11 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adar^em1Stsn/Adar^em1Stsn involves: C57BL/6J	normal embryo phenotype	J:308678
	normal growth/size/body region phenotype	J:308678
	normal mortality/aging	J:308678
Adar^em1Stsn/Adar^tm1.1Phs Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	decreased body size	J:308678
	lethality, complete penetrance	J:308678
Adar^em1Stsn/Adar^tm1Olds involves: 129S/SvEv * C57BL/6J	abnormal homeostasis	J:308678
	abnormal liver morphology	J:308678
	abnormal renal glomerulus morphology	J:308678
	abnormal spleen morphology	J:308678
	decreased body size	J:308678
	decreased circulating serum albumin level	J:308678
	expanded mesangial matrix	J:308678
	increased circulating alkaline phosphatase level	J:308678
	lethality, complete penetrance	J:308678
Adar^em2Qwan/Adar^em2Qwan Not Specified	normal growth/size/body region phenotype	J:325221
Adar^em2Qwan/Adar^em2Qwan Not Specified	normal immune system phenotype	J:325221
Adar^em3Qwan/Adar^em3Qwan Not Specified	abnormal chemokine level	J:325221
	decreased body size	J:325221
	decreased body weight	J:325221
	normal immune system phenotype	J:325221
	increased circulating interleukin-1 level	J:325221
	increased circulating interleukin-6 level	J:325221
	increased circulating interleukin-17 level	J:325221
	increased CXCL10 level	J:325221
Adar^tm1.1Knk/Adar⁺ involves: 129S1/Sv * 129X1/SvJ	normal mortality/aging	J:87714
Adar^tm1.1Knk/Adar^tm1.1Knk involves: 129S1/Sv * 129X1/SvJ	abnormal apoptosis	J:87714
	embryonic lethality during organogenesis, complete penetrance	J:87714
	normal hematopoietic system phenotype	J:87714
	increased embryonic tissue cell apoptosis	J:87714
	increased hepatocyte apoptosis	J:87714
	increased sensitivity to induced cell death	J:87714
	internal hemorrhage	J:87714
	pale yolk sac	J:87714
Adar^tm1.1Phs/Adar^tm2Phs Tg(Mx1-cre)1Cgn/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal definitive hematopoiesis	J:142338
	liver hypoplasia	J:142338
	postnatal lethality, complete penetrance	J:142338
Adar^tm1.1Phs/Adar^tm2Phs Tg(Tal1-cre/ERT)42-056Jrg/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal hematopoietic stem cell morphology	J:142338
	decreased bone marrow cell number	J:142338
Adar^{tm1b(EUCOMM)Wtsi}/Adar⁺ B6N(Cg)-Adar^{tm1b(EUCOMM)Wtsi}/J	decreased circulating glucose level	J:211773
Adar^{tm1b(EUCOMM)Wtsi}/Adar^{tm1b(EUCOMM)Wtsi} B6N(Cg)-Adar^{tm1b(EUCOMM)Wtsi}/J	abnormal embryo size	J:211773
	abnormal neural tube closure	J:211773
	abnormal placenta size	J:211773
	pale yolk sac	J:211773
	pallor	J:211773
	preweaning lethality, complete penetrance	J:211773
Adar^tm1Knk/Adar^tm1Knk Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal circulating enzyme level	J:87714
	abnormal liver morphology	J:87714
	decreased body size	J:87714
	normal hematopoietic system phenotype	J:87714
	hyperglycemia	J:87714
	increased circulating alanine transaminase level	J:87714
	increased circulating alkaline phosphatase level	J:87714
	increased circulating aspartate transaminase level	J:87714
	increased circulating lactate dehydrogenase level	J:87714
	increased hepatocyte apoptosis	J:87714
Adar^tm1Olds/Adar^tm1Olds involves: 129S/SvEv * C57BL/6J	abnormal cell physiology	J:169014
	embryonic lethality during organogenesis, complete penetrance	J:169014
	increased susceptibility to Orthomyxoviridae infection	J:169014
	increased susceptibility to Paramyxoviridae infection	J:169014
Adar^tm1Phs/Adar^tm1Phs involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal liver development	J:87715
	absent common myeloid progenitor cells	J:87715
	embryonic growth retardation	J:87715
	embryonic lethality during organogenesis, complete penetrance	J:87715
	impaired hematopoiesis	J:87715
	small liver	J:87715
Adar^tm1Phs/Adar^tm1Phs involves: 129S1/Sv * 129X1/SvJ * NMRI	abnormal liver development	J:87715
	absent common myeloid progenitor cells	J:87715
	embryonic growth retardation	J:87715
	embryonic lethality during organogenesis, complete penetrance	J:87715
	impaired hematopoiesis	J:87715
	small liver	J:87715
Adar^tm2Knk/Adar⁺ chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal embryonic erythropoiesis	J:65981
	abnormal liver development	J:65981
	embryonic lethality during organogenesis, complete penetrance	J:65981
Adar^tm2Phs/Adar^tm2Phs B6.Cg-Adar^tm2Phs	abnormal circulating interferon-beta level	J:142338
	abnormal hematopoietic stem cell morphology	J:142338
	increased circulating interferon-alpha level	J:142338
Adar^tm2Phs/Adar^tm2Phs involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal liver development	J:87715
	absent common myeloid progenitor cells	J:87715
	embryonic growth retardation	J:87715
	embryonic lethality during organogenesis, complete penetrance	J:87715
	impaired hematopoiesis	J:87715
	small liver	J:87715
Adar^tm2Phs/Adar^tm2Phs involves: 129S1/Sv * 129X1/SvJ * NMRI	abnormal liver development	J:87715
	absent common myeloid progenitor cells	J:87715
	embryonic growth retardation	J:87715
	embryonic lethality during organogenesis, complete penetrance	J:87715
	impaired hematopoiesis	J:87715
	small liver	J:87715

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