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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxo1
forkhead box O1
MGI:1890077
99 phenotypes from 13 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxo1tm1.1Dac/Foxo1tm1.1Dac
Not Specified 		abnormal blood vessel morphology J:179687
abnormal dorsal aorta morphology J:179687
abnormal embryo development J:179687
abnormal heart development J:179687
abnormal heart morphology J:179687
abnormal myocardial trabeculae morphology J:179687
abnormal somite development J:179687
abnormal somite shape J:179687
abnormal vitelline vasculature morphology J:179687
absent heartbeat J:179687
absent second pharyngeal arch J:179687
decreased somite size J:179687
embryonic growth retardation J:179687
enlarged pericardium J:179687
preweaning lethality, complete penetrance J:179687
small first pharyngeal arch J:179687
small second pharyngeal arch J:179687
Foxo1tm1.1Mrc/Foxo1tm1.1Mrc
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality, complete penetrance J:93444
Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
involves: 129S1/Sv * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:118179
Foxo1tm1.1Stlp/Foxo1tm1.1Stlp
Tg(Lck-cre)1Cwi/0
involves: 129S4/SvJae 		abnormal single-positive T cell number J:154205
decreased CD8-positive, alpha-beta T cell number J:154205
decreased double-positive T cell number J:154205
decreased T cell number J:154205
decreased T cell proliferation J:154205
decreased thymocyte apoptosis J:154205
increased CD4-positive, alpha-beta T cell number J:154205
increased CD8-positive, alpha-beta T cell number J:154205
small lymphoid organs J:154205
small spleen J:154205
Foxo1tm1b(EUCOMM)Wtsi/Foxo1+
C57BL/6N-Foxo1tm1b(EUCOMM)Wtsi/J 		decreased erythrocyte cell number J:211773
hyperactivity J:211773
increased aggression J:211773
increased circulating bilirubin level J:211773
increased mean corpuscular volume J:211773
Foxo1tm1b(EUCOMM)Wtsi/Foxo1tm1b(EUCOMM)Wtsi
C57BL/6N-Foxo1tm1b(EUCOMM)Wtsi/J 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Foxo1tm1Flv/Foxo1tm1Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal inflammatory response J:189962
abnormal regulatory T cell physiology J:189962
abnormal skin appearance J:189962
abnormal tail morphology J:189962
enlarged lymph nodes J:189962
enlarged spleen J:189962
hunched posture J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
increased interferon-gamma secretion J:189962
increased regulatory T cell number J:189962
increased T cell number J:189962
increased T cell proliferation J:189962
paralysis J:189962
premature death J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 		increased interferon-gamma secretion J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Tg(Cd4-cre)1Cwi/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:147057
abnormal CD8-positive, alpha-beta T cell physiology J:147057
abnormal T cell activation J:147057
abnormal T cell physiology J:147057
enlarged lymph nodes J:147057
increased anti-double stranded DNA antibody level J:147057
increased anti-nuclear antigen antibody level J:147057
increased single-positive T cell number J:147057
increased susceptibility to induced colitis J:147057
increased T cell proliferation J:147057
Foxo1tm1Mrc/Foxo1tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:93444
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * FVB 		normal homeostasis/metabolism phenotype J:199264
Foxo1tm1Rdp/Foxo1tm1Rdp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * C57BL/6 * DBA * FVB 		improved glucose tolerance J:137845
Foxo1tm1Rdp/Foxo1tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA * FVB/N 		increased hemangioma incidence J:118179
premature death J:118179
Foxo1tm1Tf/Foxo1tm1Tf
involves: C57BL/6J 		abnormal dorsal aorta morphology J:92247
abnormal visceral yolk sac morphology J:92247
abnormal vitelline vascular remodeling J:92247
absent organized vascular network J:92247
absent second pharyngeal arch J:92247
embryonic growth retardation J:92247
embryonic lethality during organogenesis, complete penetrance J:92247
pericardial effusion J:92247
pharyngeal arch artery hypoplasia J:92247
pharyngeal arch hypoplasia J:92247
small first pharyngeal arch J:92247
Foxo1tm1Whb/Foxo1+
Not Specified 		decreased liver glycogen level J:79560
Foxo1tm1Whb/Foxo1tm1Whb
Not Specified 		abnormal internal carotid artery morphology J:88638
abnormal intersomitic vessel morphology J:88638
absent vitelline blood vessels J:88638
delayed heart looping J:88638
distended pericardium J:88638
embryonic lethality during organogenesis, complete penetrance J:88638
Foxo1tm2.1Dac/Foxo1tm2.1Dac
B6.Cg-Foxo1tm2.1Dac 		decreased circulating tumor necrosis factor level J:179687
decreased liver cholesterol level J:179687
increased percent body fat/body weight J:179687
increased susceptibility to diet-induced obesity J:179687
Foxo1tm2.1Dac/Foxo1tm2.1Dac
Not Specified 		abnormal adipose tissue physiology J:179687
abnormal gluconeogenesis J:179687
abnormal glucose homeostasis J:179687
abnormal lipid homeostasis J:179687
decreased carbon dioxide production J:179687
decreased circulating cholesterol level J:179687
decreased circulating free fatty acids level J:179687
decreased circulating triglyceride level J:179687
decreased circulating VLDL triglyceride level J:179687
decreased energy expenditure J:179687
decreased liver triglyceride level J:179687
decreased respiratory quotient J:179687
increased circulating glucose level J:179687
increased circulating insulin level J:179687
insulin resistance J:179687
Tg(Ttr-Foxo1)305Dac/0
involves: FVB * C57BL/6 		abnormal pancreatic beta cell morphology J:79560
decreased circulating insulin level J:79560
hyperglycemia J:79560
impaired glucose tolerance J:79560
insulin resistance J:79560
Tg(Ttr-Foxo1)307Dac/0
involves: C57BL/6J 		increased circulating cholesterol level J:94423
increased circulating HDL cholesterol level J:94423
increased circulating triglyceride level J:94423
Tg(Ttr-Foxo1)307Dac/0
involves: FVB * C57BL/6 		abnormal pancreatic beta cell morphology J:79560
hyperglycemia J:79560
impaired glucose tolerance J:79560
increased circulating insulin level J:79560
increased insulin sensitivity J:79560
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory