Foxo3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxo3
forkhead box O3
MGI:1890081

73 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxo3^{Gt(VICTR20)1Kca}/Foxo3^{Gt(VICTR20)1Kca} involves: 129S5/SvEvBrd * C57BL/6	decreased mature ovarian follicle number	J:88638
	early reproductive senescence	J:88638
	impaired ovarian folliculogenesis	J:88638
	oocyte degeneration	J:88638
Foxo3^Gt(XAO26)Byg/Foxo3^Gt(XAO26)Byg involves: 129P2/OlaHsd	abnormal immune system organ morphology	J:93593
	abnormal ovarian folliculogenesis	J:93593
	abnormal T cell activation	J:93593
	abnormal T cell physiology	J:93593
	early reproductive senescence	J:93593
	enlarged lymph nodes	J:93593
	enlarged spleen	J:93593
	increased inflammatory response	J:93593
	increased T cell proliferation	J:93593
	kidney inflammation	J:93593
	lung inflammation	J:93593
	lymphoid hyperplasia	J:93593
	salivary gland inflammation	J:93593
	spleen hyperplasia	J:93593
Foxo3^mommeR1/Foxo3^mommeR1 B6.FVB-Foxo3^mommeR1	normal neoplasm	J:170710
Foxo3^mommeR1/Foxo3^mommeR1 Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew FVB/NJ-Foxo3^mommeR1 Tg(HBA1-Gfp)1Ew	abnormal oocyte morphology	J:170710
	abnormal oogenesis	J:170710
	abnormal ovarian follicle morphology	J:170710
	abnormal ovarian follicle number	J:170710
	abnormal ovary physiology	J:170710
	abnormal polar body morphology	J:170710
	abnormal primordial ovarian follicle morphology	J:170710
	abnormal superovulation	J:170710
	absent corpus luteum	J:170710
	absent ovarian follicles	J:170710
	decreased primary ovarian follicle number	J:170710
	decreased primordial ovarian follicle number	J:170710
	early reproductive senescence	J:170710
	enlarged ovary	J:170710
	increased corpora lutea number	J:170710
	increased ovarian teratoma incidence	J:170710
	increased secondary ovarian follicle number	J:170710
Foxo3^mommeR1/Foxo3^tm1.1Rdp Tg(HBA1-GFP)1Ew/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ	absent ovarian follicles	J:170710
	decreased primary ovarian follicle number	J:170710
	decreased primordial ovarian follicle number	J:170710
	normal neoplasm	J:170710
Foxo3^{tm1.1(KOMP)Vlcg}/Foxo3^{tm1.1(KOMP)Vlcg} C57BL/6N-Foxo3^{tm1.1(KOMP)Vlcg}/J	abnormal retina morphology	J:211773
	abnormal sleep behavior	J:211773
	decreased bone mineral density	J:211773
	decreased circulating chloride level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	decreased startle reflex	J:211773
	impaired glucose tolerance	J:211773
	increased heart weight	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	prolonged QRS complex duration	J:211773
	sclerocornea	J:211773
	thrombocytopenia	J:211773
Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp involves: 129S6/SvEvTac * FVB/N	abnormal estrous cycle	J:84269
	abnormal oocyte morphology	J:84269
	abnormal ovarian folliculogenesis	J:84269
	absent estrous cycle	J:84269
	anemia	J:84269
	decreased tumor latency	J:118179
	dermatitis	J:118179
	early reproductive senescence	J:84269, J:118179
	enlarged ovary	J:84269
	hemolytic anemia	J:118179
	impaired glucose tolerance	J:84269, J:118179
	increased atretic ovarian follicle number	J:84269
	increased circulating follicle stimulating hormone level	J:84269
	increased circulating luteinizing hormone level	J:84269
	increased hemangiosarcoma incidence	J:118179
	increased ovary tumor incidence	J:118179
	increased prolactinoma incidence	J:118179
	premature death	J:118179
	reduced female fertility	J:84269
	reticulocytosis	J:84269
Foxo3^tm1Nmt/Foxo3^tm1Nmt B6.Cg-Foxo3^tm1Nmt	abnormal NK cell morphology	J:123409
	decreased apoptosis	J:123409
	decreased physiological sensitivity to xenobiotic	J:123409
	increased NK cell number	J:123409
Foxo3^tm1Nmt/Foxo3^tm1Nmt involves: C57BL/6	abnormal hematopoietic stem cell morphology	J:142870
	decreased erythrocyte cell number	J:142870
	decreased hematopoietic stem cell number	J:142870
	female infertility	J:142870
	normal hematopoietic system phenotype	J:142870
	increased mean corpuscular hemoglobin	J:142870
	increased mean corpuscular volume	J:142870
	increased susceptibility to xenobiotic induced morbidity/mortality	J:142870
	reticulocytosis	J:142870
Foxo3^tm1Rdp/Foxo3^tm1Rdp Tg(Ddx4-cre)1Dcas/0 involves: 129S6/SvEvTac * FVB/N	abnormal ovary physiology	J:138697
	abnormal primordial ovarian follicle morphology	J:138697
	enlarged ovary	J:138697
Foxo3^tm1Rdp/Foxo3^tm1Rdp Tg(Ddx4-cre/ERT2)1Dcas/0 involves: 129S6/SvEvTac * FVB/N	abnormal primordial ovarian follicle morphology	J:138697
	enlarged ovary	J:138697

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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