Cdh23 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdh23
cadherin related 23 (otocadherin)
MGI:1890219

108 phenotypes from 27 alleles in 36 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdh23^12J/Cdh23^12J involves: C3H/HeJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:183808
	abnormal cochlear hair cell stereociliary bundle morphology	J:183808
	abnormal distortion product otoacoustic emission	J:183808
	abnormal outer hair cell stereociliary bundle morphology	J:183808
	cochlear hair cell degeneration	J:183808
	cochlear inner hair cell degeneration	J:183808
	cochlear outer hair cell degeneration	J:183808
	deafness	J:183808
	decreased cochlear hair cell stereocilia number	J:183808
	increased or absent threshold for auditory brainstem response	J:183808
	organ of Corti degeneration	J:183808
Cdh23^12J/Cdh23^12J involves: C57BL/6J	abnormal auditory brainstem response	J:174758
	abnormal cochlear outer hair cell physiology	J:174758
	abnormal distortion product otoacoustic emission	J:174758
	absent distortion product otoacoustic emissions	J:174758
	absent pinna reflex	J:174758
	normal behavior/neurological phenotype	J:174758
	deafness	J:174758
	decreased cochlear inner hair cell number	J:174758
	decreased cochlear outer hair cell number	J:174758
	normal hearing/vestibular/ear phenotype	J:174758
	impaired hearing	J:174758
Cdh23^12J/Cdh23^v-2J involves: C57BL/6J	increased or absent threshold for auditory brainstem response	J:183808
Cdh23^ahl/Cdh23^ahl C57BL/6J	cochlear ganglion hypoplasia	J:87783
Cdh23^ahl/Cdh23^ahl C57BL/6J	organ of Corti degeneration	J:87783
Cdh23^ahl/Cdh23^ahl C57BL/6NJ	cochlear hair cell degeneration	J:241137
	cochlear inner hair cell degeneration	J:241137
	cochlear outer hair cell degeneration	J:241137
Cdh23^ahl/Cdh23^ahl multiple strains	increased susceptibility to age-related hearing loss	J:86905
Cdh23^Jera/Cdh23⁺ involves: C57BL/6	cochlear outer hair cell degeneration	J:174130
Cdh23^Jera/Cdh23⁺ involves: C57BL/6	increased or absent threshold for auditory brainstem response	J:174130
Cdh23^Jera/Cdh23^Jera involves: C57BL/6	abnormal cochlear ganglion morphology	J:174130
	abnormal inner hair cell stereociliary bundle morphology	J:174130
	abnormal organ of Corti morphology	J:174130
	normal behavior/neurological phenotype	J:174130
	cochlear hair cell degeneration	J:174130
	normal hearing/vestibular/ear phenotype	J:174130
	impaired hearing	J:174130
	increased or absent threshold for auditory brainstem response	J:174130
	organ of Corti degeneration	J:174130
Cdh23^m1Btlr/Cdh23^m1Btlr C57BL/6J-Cdh23^m1Btlr	head bobbing	J:201320
Cdh23^m2Btlr/Cdh23^m2Btlr C57BL/6J-Cdh23^m2Btlr	circling	J:267489
Cdh23^m2Btlr/Cdh23^m2Btlr C57BL/6J-Cdh23^m2Btlr	decreased body weight	J:267489
Cdh23^sals/Cdh23^sals involves: C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:147149
	abnormal cochlear hair cell morphology	J:147149
	abnormal cochlear hair cell physiology	J:147149
	abnormal hearing physiology	J:147149
	absent distortion product otoacoustic emissions	J:147149
	normal behavior/neurological phenotype	J:147149
	cochlear ganglion degeneration	J:147149
	cochlear hair cell degeneration	J:147149
	decreased startle reflex	J:119820
	normal hearing/vestibular/ear phenotype	J:147149
	impaired hearing	J:147149
	increased or absent threshold for auditory brainstem response	J:119820, J:147149
	organ of Corti degeneration	J:147149
Cdh23^sals/Cdh23^v-2J involves: C57BL/6J	deafness	J:147149
Cdh23^tm1.1Kjn/Cdh23^tm1.1Kjn 129S/Sv-Cdh23^tm1.1Kjn/Kjn	decreased cochlear hair cell number	J:241137
	decreased cochlear inner hair cell number	J:241137
	decreased cochlear outer hair cell number	J:241137
	increased or absent threshold for auditory brainstem response	J:241137
Cdh23^tm1.1Ugds/Cdh23^tm1.1Ugds involves: 129S1/SvImJ * C57BL/6	normal behavior/neurological phenotype	J:158897
Cdh23^tm1.1Ugds/Cdh23^tm1.1Ugds Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ involves: 129S1/SvImJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:171218
	abnormal hearing electrophysiology	J:171218
	abnormal inner hair cell stereociliary bundle morphology	J:171218
	abnormal outer hair cell stereociliary bundle morphology	J:171218
	absent cochlear microphonics	J:171218
	absent distortion product otoacoustic emissions	J:171218
	decreased inner hair cell stereocilia number	J:171218
	decreased outer hair cell stereocilia number	J:171218
	impaired hearing	J:171218
	increased or absent threshold for auditory brainstem response	J:171218
	short inner hair cell stereocilia	J:171218
	short outer hair cell stereocilia	J:171218
Cdh23^tm1.2Ugds/Cdh23^tm1.2Ugds involves: 129S1/SvImJ	abnormal hair cell mechanoelectric transduction	J:171218
Cdh23^tm1.2Ugds/Cdh23^tm1.2Ugds involves: 129S1/SvImJ * BALB/c * C57BL/6	abnormal cochlear outer hair cell morphology	J:158897
	abnormal outer hair cell stereociliary bundle morphology	J:158897
Cdh23^tm2.1Kjn/Cdh23^tm2.1Kjn B6N(Cg)-Cdh23^tm2.1Kjn/Kjn	normal hearing/vestibular/ear phenotype	J:241137
Cdh23^{tm2b(EUCOMM)Wtsi}/Cdh23^{tm2b(EUCOMM)Wtsi} C57BL/6N-Cdh23^{tm2b(EUCOMM)Wtsi}/Wtsi	abnormal gait	J:211773
	absent pinna reflex	J:211773
	decreased body length	J:211773
	decreased circulating calcium level	J:211773
	decreased circulating glucose level	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased leukocyte cell number	J:211773
	decreased total body fat amount	J:211773
	impaired righting response	J:211773
	increased bone mineral content	J:211773
	increased circulating chloride level	J:211773
	increased circulating sodium level	J:211773
	increased lean body mass	J:211773
	increased mean corpuscular hemoglobin	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	stereotypic behavior	J:211773
	trunk curl	J:211773
Cdh23^v-2J/Cdh23⁺ B6(V)-Cdh23^v-2J/J	increased or absent threshold for auditory brainstem response	J:183898
Cdh23^v-2J/Cdh23⁺ mixed	absent pinna reflex	J:108877
Cdh23^v-2J/Cdh23⁺ mixed	increased susceptibility to age-related hearing loss	J:108877
Cdh23^v-2J/Cdh23^v-2J B6(V)-Cdh23^v-2J/J	abnormal cochlear hair bundle tip links morphology	J:135991
	abnormal cochlear hair cell inter-stereocilial links morphology	J:135991
	abnormal cochlear outer hair cell morphology	J:66698
	abnormal ear morphology	J:66698
	abnormal ear physiology	J:66698
	abnormal eye electrophysiology	J:109546
	abnormal inner hair cell kinocilium morphology	J:135991
	abnormal inner hair cell stereociliary bundle morphology	J:66698, J:135991
	abnormal orientation of cochlear hair cell stereociliary bundles	J:135991
	abnormal outer hair cell kinocilium morphology	J:135991
	abnormal outer hair cell stereociliary bundle morphology	J:66698, J:135991
	abnormal reflex	J:116914
	abnormal vestibular hair cell stereociliary bundle morphology	J:66698
	absent linear vestibular evoked potential	J:116914
	absent outer hair cell stereocilia	J:66698
	circling	J:116914
	decreased a-wave implicit time	J:109546
	decreased b-wave implicit time	J:109546
	decreased outer hair cell stereocilia number	J:66698
	impaired swimming	J:116914
	increased or absent threshold for auditory brainstem response	J:66698
	normal vision/eye phenotype	J:109546
Cdh23^v-2J/Cdh23^v-2J involves: C57BL/6J	abnormal cochlear hair cell physiology	J:186316
Cdh23^v-3J/Cdh23⁺ C57BL/6J-Cdh23^v-3J	abnormal vestibular system physiology	J:73941
	ataxia	J:73941
	increased or absent threshold for auditory brainstem response	J:73941
Cdh23^v-4J/Cdh23^v-4J involves: C57BLKS/J	circling	J:49039
	deafness	J:49039
	head bobbing	J:49039
	hyperactivity	J:49039
Cdh23^v-5J/Cdh23^v-5J involves: SENCARA/PtJ	circling	J:49035
	deafness	J:49035
	head bobbing	J:49035
Cdh23^v-6J/Cdh23^v-6J B10.A-H2^h4/(4R)SgDvEgJ-Cdh23^v-6J/J	increased or absent threshold for auditory brainstem response	J:66698
Cdh23^v-7J/Cdh23^v-7J CByJ(Cg)-Cdh23^v-7J/GrsrJ	abnormal inner ear morphology	J:97759
	circling	J:97759
	cochlear ganglion degeneration	J:97759
	deafness	J:97759
	head tossing	J:97759
	hyperactivity	J:97759
	organ of Corti degeneration	J:97759
	stria vascularis degeneration	J:97759
	vestibular saccular degeneration	J:97759
Cdh23^v-8J/Cdh23^v-8J C57BL/6J-Cdh23^v-8J/J	abnormal auditory brainstem response	J:82238
	circling	J:82238
	deafness	J:82238
	head tilt	J:82238
Cdh23^v-9J/Cdh23^v-9J C57BL/6J-Cdh23^v-9J/J	abnormal auditory brainstem response	J:82238
	circling	J:82238
	deafness	J:82238
Cdh23^v-10J/Cdh23^v-10J involves: BALB/cByJ * C57BL/6	abnormal auditory brainstem response	J:87349
	abnormal stationary movement	J:87349
	circling	J:87349
	deafness	J:87349
	head tilt	J:87349
Cdh23^v-11J/Cdh23^v-11J B6(Cg)-Cdh23^v-11J/J	circling	J:135835
	deafness	J:135835
	head bobbing	J:135835
	increased or absent threshold for auditory brainstem response	J:135835
	organ of Corti degeneration	J:135835
	normal vision/eye phenotype	J:135835
Cdh23^v-Alb/Cdh23^v-Alb involves: C3H/HeJ * C57BL/6	abnormal cochlear outer hair cell morphology	J:66698
	abnormal ear morphology	J:66698
	abnormal ear physiology	J:66698
	abnormal inner hair cell stereociliary bundle morphology	J:66698
	abnormal outer hair cell kinocilium location or orientation	J:66698
	abnormal outer hair cell stereociliary bundle morphology	J:66698
	abnormal vestibular hair cell stereociliary bundle morphology	J:66698
	absent outer hair cell stereocilia	J:66698
	bidirectional circling	J:38058
	deafness	J:38058
	decreased litter size	J:38058
	decreased outer hair cell stereocilia number	J:66698
	head tossing	J:38058
	hyperactivity	J:38058
Cdh23^v-Alb/Cdh23^v-Alb involves: C3H/HeJ * C57BL/6 * CBA/Ca	normal vision/eye phenotype	J:109546
Cdh23^v-bus/Cdh23^v-bus involves: KYF/MsIdr	abnormal cochlea morphology	J:34019
	abnormal cochlear ganglion morphology	J:34019
	abnormal cochlear hair cell morphology	J:34019, J:174759
	abnormal cochlear sensory epithelium morphology	J:39748
	abnormal inner hair cell stereociliary bundle morphology	J:34019
	abnormal maternal nurturing	J:12975
	abnormal organ of Corti morphology	J:34019
	abnormal orientation of inner hair cell stereociliary bundles	J:34019
	abnormal orientation of outer hair cell stereociliary bundles	J:34019
	abnormal outer hair cell stereociliary bundle morphology	J:34019
	abnormal startle reflex	J:34019
	absent startle reflex	J:34019
	circling	J:57150
	decreased cochlear hair cell number	J:39748
	head tilt	J:57150
	head tossing	J:57150
	hyperactivity	J:12975
Cdh23^v-df/Cdh23^v-df Not Specified	abnormal cochlear ganglion morphology	J:12997
	abnormal ear position	J:12997
	abnormal motor capabilities/coordination/movement	J:12997
	abnormal stria vascularis morphology	J:12997
	absent pinna reflex	J:12997
	deafness	J:12997
	organ of Corti degeneration	J:12997
Cdh23^v-J/Cdh23^v-J B6.C-H2-K^bm1/ByJ	abnormal otolith morphology	J:29159
	ataxia	J:29159
	head tossing	J:29159
	increased or absent threshold for auditory brainstem response	J:29159
	novel environmental response-related retropulsion	J:29159
Cdh23^v-ngt/Cdh23^v-ngt involves: ICR * MSM	abnormal cochlear outer hair cell morphology	J:69028
	abnormal outer hair cell stereociliary bundle morphology	J:69028
	absent pinna reflex	J:69028
	circling	J:69028
	deafness	J:69028
	head shaking	J:69028
Cdh23^v/Cdh23⁺ involves: BALB/cRl * 47BS/Rl * CBA/Ca	abnormal cochlear nerve compound action potential	J:134369
	abnormal outer hair cell stereociliary bundle morphology	J:134369
	decreased cochlear inner hair cell number	J:134369
	decreased cochlear outer hair cell number	J:134369
	decreased outer hair cell stereocilia number	J:134369
	impaired hearing	J:134369
	increased susceptibility to age-related hearing loss	J:134369
	increased susceptibility to noise-induced hearing loss	J:134369
Cdh23^v/Cdh23⁺ mixed	absent pinna reflex	J:108877
Cdh23^v/Cdh23⁺ mixed	increased susceptibility to age-related hearing loss	J:108877
Cdh23^v/Cdh23^v involves: CBA/Ca	abnormal eye electrophysiology	J:109546
	abnormal inner hair cell stereociliary bundle morphology	J:108877
	abnormal outer hair cell stereociliary bundle morphology	J:108877
	normal vision/eye phenotype	J:109546
Cdh23^v/Cdh23^v involves: fancier's stocks	abnormal defecation	J:133042
	abnormal gait	J:133042
	abnormal locomotor behavior	J:133042
	abnormal response to novelty	J:133042
	abnormal stationary movement	J:133042
	circling	J:133042
	deafness	J:133042
	decreased grooming behavior	J:133042
	decreased vertical activity	J:133042
	head shaking	J:133042
	tremors	J:133042
Cdh23^v/Cdh23^v mixed	cochlear ganglion degeneration	J:13130
	cochlear hair cell degeneration	J:13130
	impaired swimming	J:13130
	vestibular saccular macula degeneration	J:13130
Cdh23^v/Cdh23^v V/LeJ	normal homeostasis/metabolism phenotype	J:29151

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