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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
MGI:1890357
51 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Igf2bp1em1(IMPC)J/Igf2bp1+
C57BL/6NJ-Igf2bp1em1(IMPC)J/Mmjax 		decreased locomotor activity J:211773
hyperactivity J:211773
Igf2bp1em1(IMPC)J/Igf2bp1em1(IMPC)J
C57BL/6NJ-Igf2bp1em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
involves: 129S5/SvEvBrd 		abnormal cell cycle J:207231
abnormal cerebral cortex morphology J:207231
abnormal CNS glial cell morphology J:207231
abnormal lateral ventricle morphology J:207231
abnormal neuronal stem cell morphology J:207231
decreased brain size J:207231
decreased cell proliferation J:207231
decreased neuronal stem cell self-renewal J:207231
premature neuronal precursor differentiation J:207231
Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal cartilage morphology J:89882
abnormal colon goblet cell morphology J:89882
abnormal eating behavior J:89882
abnormal intestinal mucosa morphology J:89882
abnormal intestinal smooth muscle morphology J:89882
abnormal intestine morphology J:89882
abnormal kidney collecting duct morphology J:89882
abnormal large intestine crypts of Lieberkuhn morphology J:89882
abnormal liver lobule morphology J:89882
abnormal renal glomerulus morphology J:89882
abnormal small intestinal microvillus morphology J:89882
abnormal small intestine morphology J:89882
anemia J:89882
circling J:89882
decreased birth weight J:89882
decreased body length J:89882
decreased body weight J:89882
decreased cell proliferation J:89882
decreased fetal weight J:89882
decreased locomotor activity J:89882
decreased placenta weight J:89882
decreased small intestinal villus size J:89882
decreased survivor rate J:89882
dehydration J:89882
delayed intestine development J:89882
delayed kidney development J:89882
disproportionate dwarf J:89882
fetal growth retardation J:89882
hepatic steatosis J:89882
hyperactivity J:89882
increased aggression J:89882
kinked tail J:89882
perinatal lethality, incomplete penetrance J:89882
postnatal growth retardation J:89882
postnatal lethality, incomplete penetrance J:89882
renal hypoplasia J:89882
short snout J:89882
spleen hypoplasia J:89882
Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		decreased exploration in new environment J:103485
increased anxiety-related response J:103485
preweaning lethality, incomplete penetrance J:103485
Igf2bp1Gt(XL009)Byg/Igf2bp1Gt(XL009)Byg
involves: 129P2/OlaHsd 		abnormal cell physiology J:187686
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory