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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Paxip1
PAX interacting (with transcription-activation domain) protein 1
MGI:1890430
35 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Paxip1L5Jcs4/Paxip1L5Jcs4
involves: C57BL/6 		abnormal aortic arch development J:140559
abnormal placenta vasculature J:140559
abnormal vasculogenesis J:140559
abnormal vitelline vasculature morphology J:140559
decreased embryo size J:140559
distended pericardium J:140559
embryonic lethality during organogenesis, complete penetrance J:140559
embryonic lethality, complete penetrance J:100332
pale yolk sac J:140559
placental labyrinth hypoplasia J:140559
Paxip1L5Jcs36/Paxip1L5Jcs36
involves: C57BL/6 		abnormal allantois morphology J:140559
absent organized vascular network J:140559
caudal body truncation J:140559
decreased embryo size J:140559
embryonic growth retardation J:140559
embryonic lethality between implantation and somite formation, complete penetrance J:100332
embryonic lethality during organogenesis, complete penetrance J:140559
failure of chorioallantoic fusion J:140559
failure of heart looping J:140559
incomplete embryo turning J:140559
pallor J:140559
Paxip1tm1Gdr/Paxip1tm1Gdr
involves: 129S1/Sv * 129X1/SvJ 		embryonic growth retardation J:140559
embryonic lethality, complete penetrance J:140559
Paxip1tm1Gdr/Paxip1tm1Gdr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal allantois morphology J:82319
abnormal developmental patterning J:82319
abnormal DNA repair J:82319
abnormal egg cylinder morphology J:82319
abnormal heart development J:82319
abnormal mitosis J:82319
abnormal vitelline vasculature morphology J:82319
absent amnion J:82319
decreased cell proliferation J:82319
decreased DNA replication J:82319
decreased embryo size J:82319
decreased inner cell mass proliferation J:82319
disorganized embryonic tissue J:82319
embryonic growth arrest J:82319
embryonic lethality, complete penetrance J:82319
incomplete somite formation J:82319
increased cellular sensitivity to ionizing radiation J:82319
increased embryonic tissue cell apoptosis J:82319
Paxip1tm2Gdr/Paxip1tm2Gdr
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:128440
Paxip1tm2Gdr/Paxip1tm2Gdr
Tg(Nes-cre)1Atp/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		neonatal lethality, complete penetrance J:128440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory