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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il21
interleukin 21
MGI:1890474
17 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il21tm1.1(KOMP)Mbp/Il21tm1.1(KOMP)Mbp
C57BL/6NCrl-Il21tm1.1(KOMP)Mbp/MbpMmucd 		enlarged testis J:211773
Il21tm1Lex/Il21tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:137867
abnormal CD4-positive, alpha-beta T cell physiology J:137867
abnormal germinal center B cell physiology J:137867
abnormal spleen germinal center morphology J:137867
decreased germinal center B cell number J:137867
decreased IgG1 level J:137867
decreased spleen germinal center number J:137867
Il21tm1Lex/Il21tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal gamma-delta T cell morphology J:123351
abnormal interleukin level J:123351
abnormal T cell differentiation J:123351
decreased CD4-positive, alpha-beta T cell number J:123351
decreased susceptibility to experimental autoimmune encephalomyelitis J:123351
increased susceptibility to experimental autoimmune encephalomyelitis J:137377
Il21tm1Llit/Il21tm1Llit
involves: 129 * C57BL/6J 		abnormal class switch recombination J:114783
increased IgE level J:114783
Il21tm1Nutt/Il21+
involves: C57BL/6 		no abnormal phenotype detected J:185372
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory